Sökning: "AMPK"

Visar resultat 1 - 5 av 53 avhandlingar innehållade ordet AMPK.

  1. 1. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

    Författare :Loubna Bendrioua; Göteborgs universitet.; Gothenburg University.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

    Sammanfattning : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. LÄS MER

  2. 2. Protein kinases in hormonal regulation of adipocyte metabolism

    Detta är en avhandling från Protein Phosphorylation, Faculty of Medicine

    Författare :Christine Berggreen; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Sammanfattning : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. LÄS MER

  3. 3. Glucotoxicity in Insulin-Producing β-Cells

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Hanna K Nyblom; Uppsala universitet.; [2007]
    Nyckelord :Cell biology; type 2 diabetes; SELDI-TOF MS; glucotoxicity; proteomics; insulin secretion; mitochondria; lipids; INS-1E cells; GC-MS; HR-MAS NMR; metabolomics; human islet; AMPK; AICAR; ER stress; apoptosis; Cellbiologi;

    Sammanfattning : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. LÄS MER

  4. 4. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Erna Raja; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell signalling; TGFbeta; BMP; LKB1; AMPK; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. LÄS MER

  5. 5. Detecting novel effects of exercise or AMPK activation in human skeletal muscle

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :David Gray Lassiter; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine monophosphate-activated protein kinase (AMPK). LÄS MER