Sökning: "AMPK"

Visar resultat 1 - 5 av 58 avhandlingar innehållade ordet AMPK.

  1. 1. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

    Författare :Loubna Bendrioua; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

    Sammanfattning : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. LÄS MER

  2. 2. AMP-activated protein kinase in adipose tissue

    Författare :Franziska Kopietz; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AMPK; adipose tissue; adipocytes; diabetes; insulin; glucose uptake; lipolysis; FA synthesis; ADaM site activators;

    Sammanfattning : The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. LÄS MER

  3. 3. Protein kinases in hormonal regulation of adipocyte metabolism

    Författare :Christine Berggreen; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Sammanfattning : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. LÄS MER

  4. 4. Glucotoxicity in Insulin-Producing β-Cells

    Författare :Hanna K Nyblom; Peter Bergsten; Michael Welsh; Miriam Cnop; Uppsala universitet; []
    Nyckelord :Cell biology; type 2 diabetes; SELDI-TOF MS; glucotoxicity; proteomics; insulin secretion; mitochondria; lipids; INS-1E cells; GC-MS; HR-MAS NMR; metabolomics; human islet; AMPK; AICAR; ER stress; apoptosis; Cellbiologi;

    Sammanfattning : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. LÄS MER

  5. 5. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors

    Författare :Andris Elksnis; Per-Ola Carlsson; Nils Welsh; Sergiu-Bogdan Catrina; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; Tyrosine kinase inhibitors; Imatinib; AMPK; Oxidative stress; NADPH-oxidase; NOX; NOX4; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. LÄS MER