Sökning: "NO-cGMP"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet NO-cGMP.

  1. 1. Pharmacological evaluation of the NO/cGMP signalling system

    Författare :Anna Asplund Persson; Karl-Erik Andersson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Platelet activation and inhibition are tightly balanced processes, regulated by various endogenous molecules. In this regard, the endothelium plays a key role in mediating inhibition of platelets by releasing nitric oxide (NO) and cAMP-elevating prostaglandins. LÄS MER

  3. 2. Expression and regulation of neuronal messenger molecules : focus on the NO-cGMP pathway and galanin in autonomic and sensory neurons

    Författare :Kristina Holmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adrenal gland; autonomic ganglia; cGMP; dorsal root ganglion; galanin; immunohistochemistry; in situ hybridization; nerve growth factor; neuropeptides; nitric oxide synthase; sodium nitroprusside; transgenic mice;

    Sammanfattning : The autonomic nervous system consists of the sympathetic, parasympathetic and enteric divisions. The sympathetic pre- and paravertebral neurons are in principle of noradrenergic phenotype. However, originally pharmacological experiments indicated that sympathetic fibers projecting to the sweat glands are cholinergic. LÄS MER

  4. 3. Nutrient and energy sensing in skeletal muscle

    Författare :Atul S Deshmukh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; AMPK; mTOR; glucose metabolism; exercise; Akt; TBC1D1 D4; CaMK; NO-cGMP;

    Sammanfattning : Nutrient overload and physical inactivity often leads to the development of obesity and type 2 diabetes. Acute over-nutrition can induce insulin resistance, while physical exercise enhances skeletal muscle insulin sensitivity. Like every living cell, skeletal muscle senses nutrient and energy signals and to adjust metabolic flux. LÄS MER

  5. 4. Nitric oxide modulates neutrophil function

    Författare :Tony Forslund; Per Venge; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : An important role of the neutrophils is to attack and destroy microbial intruders. In order to do so, these leukocytes must adhere to the blood vessel wall, pass through the endothelial cell layer, move through the tissues to the point of infection, ingest the intruder and destroy it. LÄS MER

  7. 5. The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia

    Författare :Kim Fejgin; Göteborgs universitet; []
    Nyckelord :schizophrenia; nitric oxide; prepulse inhibition; phencyclidine; prefrontal cortex; cGMP; baclofen; cognition;

    Sammanfattning : The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly observed in patients with schizophrenia. LÄS MER