Sökning: "Copy number changes"

Visar resultat 16 - 20 av 72 avhandlingar innehållade orden Copy number changes.

  1. 16. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer

    Författare :Ingrid Ljuslinder; Beatrice Malmer; Håkan Hedman; Roger Henriksson; Irina Golovleva; Mef Nilbert; Umeå universitet; []
    Nyckelord :breast cancer; colorectal cancer; LRIG1; EGFR; ERBB2; invasive margin; onkologi; Oncology;

    Sammanfattning : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). LÄS MER

  3. 17. Pharmacovigilance : spontaneous reporting in health care

    Författare :Elisabet Ekman; Göran Petersson; Susanna Wallerstedt; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacovigilance; adverse drug reaction; spontaneous reporting; nurses; physicians; attitudes; torsades de pointes; erectile dysfunction; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Pharmacovigilance in healthcare is essential for safe drug treatment. Spontaneous reporting is the most common source of information in the context of implementing label changes and taking a drug off the market. However, underreporting is found to be very prevalent. LÄS MER

  4. 18. Textmedierade virtuella världar : Narration, perception och kognition

    Författare :Ulf Pettersson; Lars Elleström; Paul Tenngart; Linnéuniversitetet; []
    Nyckelord :HUMANIORA; HUMANITIES; intermediality; virtual worlds; possible worlds; fictional worlds; storyworlds; reader response; semiotics; Gestalt psychology; cognitive linguistics; cognitive psychology; cognitive poetics; reading process; mental models; situation models; schemata; scripts; narratology; diegetic levels; focalization; transactional theory; iconicity; immersion; aesthetic illusion; gaps; concretization; mental places; integration network models; blending; conceptual metaphors; Intermedialitet; läsprocess; mentala bilder; mentala modeller; möjliga världar; fiktionsvärldar; virtuella världar; mentala platser; semiotik; kognitionsforskning; kognitiv semantik; kognitiv lingvistik; kognitiv poetik; narratologi; fokalisering; diegetiska nivåer; luckor; schemata; scripts; estetisk illusion; ikonicitet;

    Sammanfattning : This thesis synthezises theories from intermedia studies, semiotics, Gestalt psychology, cognitive linguistics, cognitive psychology, cognitive poetics, reader response criticism, narratology and possible worlds-theories adjusted to literary studies. The aim is to provide a transdisciplinary explanatory model of the transaction between text and reader during the reading process resulting in the reader experiencing a mental, virtual world. LÄS MER

  5. 19. Sharecom internationalisation : Exploring business models, business ecosystems, and pathways to international expansion

    Författare :Heidi Coral Thornton; Richard A. Owusu; Emilia Rovira Nordman; Linnéuniversitetet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; sharing economy; sharecom; digital platform; business model; business ecosystem; entry strategy; internationalisation pathway; internationalisation; Business administration; Företagsekonomi;

    Sammanfattning : An ever-changing business landscape, rapid developments in digital technologies, and shifts in societal attitudes have paved the way for the sharing economy phenomenon. Over the past decade, sharing economy companies (sharecoms) have emerged in droves, shaking up industry structures globally with their innovative business models and novel valuecreating processes, which rely on the externalised resources. LÄS MER

  7. 20. Essays on Efficiency, Productivity, and Impact of Policy

    Författare :Pontus Mattsson; Jonas Månsson; Lars Behrenz; Almas Heshmati; Linnéuniversitetet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; conditional difference-in-differences cDiD ; courts; data envelopment analysis DEA ; Malmquist index; horizontal mergers; impacts of policy; stochastic frontier analysis SFA ; subsidized employment; total factor productivity TFP ; Törnqvist TFP index; Economics; Nationalekonomi;

    Sammanfattning : This thesis consists of five self-contained empirical essays centering on total factor productivity (TFP), efficiency, and impacts of policy.Essay I: “TFP Change and Its Components for Swedish Manufacturing Firms During the 2008-2009 Financial Crisis” (co-authored with Jonas Månsson and William H. Greene). LÄS MER