Sökning: "dual targeting"
Visar resultat 1 - 5 av 60 avhandlingar innehållade orden dual targeting.
1. One key to two doors : Dual targeting peptides and membrane mimetics
Sammanfattning : A targeting peptide at the N-terminus of a precursor protein usually directs the protein synthesized in the cytosol to a specific organelle in the cell. Interestingly, some targeting peptides, so-called dual targeting peptides (dTPs) can target their protein to both mitochondria and chloroplasts. LÄS MER
2. Dual targeting of proteins to mitochondria and chloroplasts : Characterization of dual targeting peptides and their interaction with organellar receptors
Sammanfattning : Most mitochondrial and chloroplastic proteins are synthesized in the cytosol as precursor proteins with an N-terminal targeting peptide (TP), which directs them to the correct organelle. There is also a group of proteins that are dual targeted to mitochondria and chloroplasts using an ambiguous N-terminal dual targeting peptide (dTP). LÄS MER
3. Dual targeting of glutathione reductase to mitochondria and chloroplasts
Sammanfattning : As a consequence of the presence of both mitochondria and chloroplasts in plant cells there is a higher sorting requirement in a plant cell than that in a non-plant cell. Reflecting this, protein import to mitochondria and chloroplasts has been shown to be highly specific. LÄS MER
4. Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
Sammanfattning : Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack of suitable vectors. LÄS MER
5. Dual Targeting of Proteins to Mitochondria and Chloroplasts
Sammanfattning : The vast majority of mitochondrial and chloroplastic proteins are nuclear encoded, synthesized in the cytosol and imported into the respective organelle using an N-terminal extension, the targeting peptide (TP). After import into the organelle, the TP is cleaved off and degraded by the Presequence protease (PreP). LÄS MER