Sökning: "integration network models"

Visar resultat 1 - 5 av 96 avhandlingar innehållade orden integration network models.

  1. 1. Functional association networks for disease gene prediction

    Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER

  3. 2. Textmedierade virtuella världar : Narration, perception och kognition

    Författare :Ulf Pettersson; Lars Elleström; Paul Tenngart; Linnéuniversitetet; []
    Nyckelord :HUMANIORA; HUMANITIES; intermediality; virtual worlds; possible worlds; fictional worlds; storyworlds; reader response; semiotics; Gestalt psychology; cognitive linguistics; cognitive psychology; cognitive poetics; reading process; mental models; situation models; schemata; scripts; narratology; diegetic levels; focalization; transactional theory; iconicity; immersion; aesthetic illusion; gaps; concretization; mental places; integration network models; blending; conceptual metaphors; Intermedialitet; läsprocess; mentala bilder; mentala modeller; möjliga världar; fiktionsvärldar; virtuella världar; mentala platser; semiotik; kognitionsforskning; kognitiv semantik; kognitiv lingvistik; kognitiv poetik; narratologi; fokalisering; diegetiska nivåer; luckor; schemata; scripts; estetisk illusion; ikonicitet;

    Sammanfattning : This thesis synthezises theories from intermedia studies, semiotics, Gestalt psychology, cognitive linguistics, cognitive psychology, cognitive poetics, reader response criticism, narratology and possible worlds-theories adjusted to literary studies. The aim is to provide a transdisciplinary explanatory model of the transaction between text and reader during the reading process resulting in the reader experiencing a mental, virtual world. LÄS MER

  4. 3. Large scale integration and interactive exploration of cancer data – with applications to glioblastoma

    Författare :Patrik Johansson; Sven Nelander; Rebecka Jörnsten; Lene Uhrbom; Gary Bader; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; data integration; network modeling; interactive exploration; precision medicine; Oncology; Onkologi; Molekylär medicin; Molecular Medicine; Statistics; Statistik;

    Sammanfattning : Glioblastoma is the most common malignant brain tumor, with a median survival of approximately 15 months. The standard of care treatment consists of surgical resection followed by radiotherapy and chemotherapy, where chemotherapy only prolongs survival by approximately 3 months. LÄS MER

  5. 4. Computational problem solving in university physics education : Students’ beliefs, knowledge, and motivation

    Författare :Madelen Bodin; Mikael Winberg; Diane Grayson; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; physics education; computational physics; simulation; beliefs; motivation; mental models; network analysis; didactics of physics; fysikdidaktik;

    Sammanfattning : Solving physics problem in university physics education with a computational approach requires knowledge and skills in several domains, for example, physics, mathematics, programming, and modelling. These competences are in turn related to students' beliefs about these domains as well as about learning, and their motivation to learn. LÄS MER

  7. 5. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration

    Författare :Saeed Shoaie; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; meta’omics; complexity; obesity; network topology; Gut microbiome; genome-scale metabolic model; gene richness; CASINO; systems biology; flux balance analysis; diabetes;

    Sammanfattning : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. LÄS MER