Sökning: "Clinical trial design"

Visar resultat 1 - 5 av 146 avhandlingar innehållade orden Clinical trial design.

  1. 1. The inflammatory response to traumatic brain injury and a potential cure for it

    Författare :David Cederberg; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TBI traumatic brain injury; Neuroinflammation; clinical trial; Clinical trial design;

    Sammanfattning : .... LÄS MER

  3. 2. Depression in teenagers and young adults : foundational studies of the new treatment paradigm TARA: Training for Awareness, Resilience, and Action

    Författare :Erik Ekbäck; Eva Henje Blom; Ida Blomqvist; Jenny Molin; Inga Dennhag; Thorbjörn Lundberg; Elizabeth McCauley; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; adolescents; young adults; medical students; mental health; anxiety; psychological stress; qualitative research; randomization; yoga; mindfulness; psychotherapy; antidepressant drugs; biomarkers; clinical trial; feasibility studies; online intervention; reliability; validity; confirmatory factor analysis; measurement invariance; barn- och ungdomspsykiatri; Child and Youth Psychiatry;

    Sammanfattning : Introduction: Depression in adolescents and young adults is an increasing global health concern and available treatments are not convincingly effective. It is therefore important to develop and test novel treatments to improve treatment outcomes. LÄS MER

  4. 3. Model-Based Optimization of Clinical Trial Designs

    Författare :Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

  5. 4. On Sequential Treatment Allocations in Clinical Trials

    Författare :Carl-Fredrik Burman; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; treatment assignment; clinical trial; biased coin designs; balance of prognostic factors; sequential design; randomization test; expected p-value; deficiency; efficiency; efficiency;

    Sammanfattning : This dissertation treats baseline-dependent sequential designs of two-treatment parallel-group clinical trials. The treatment assignments are chosen in order to minimize the variance, in a linear model, of the treatment effect. This is done for each new allocation using a generalized biased coin design, or a non-randomized minimization' method. LÄS MER

  7. 5. Pooling Data from Similar Randomized Clinical Trials Comparing Latanoprost with Timolol; Medical Results and Statistical Aspects

    Författare :Katarina Hedman; Albert Alm; Adam Taube; T Joseph Sheehan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; mean intraocular pressure; target intraocular pressure; latanoprost; timolol; open-angle glaucoma; ocular hypertension; trial design; Oftalmiatrik; Ophtalmology; Oftalmologi; Ophtalmology; oftalmiatrik;

    Sammanfattning : Two different principles were studied. 1st - statistical analysis techniques were used to obtain medical results from a patient population. 2nd - the patient population was used to study the statistical analysis techniques. LÄS MER