Sökning: "randomization"

Visar resultat 1 - 5 av 100 avhandlingar innehållade ordet randomization.

  1. 1. Optimal adaptive designs and adaptive randomization techniques for clinical trials

    Författare :Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

    Sammanfattning : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. LÄS MER

  2. 2. Philosophical controversies in the evaluation of medical treatments : With a focus on the evidential roles of randomization and mechanisms in Evidence-Based Medicine

    Författare :Alexander Mebius; John Cantwell; Jeremy Howick; Sven Ove Hansson; Julian Reiss; KTH; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HUMANITIES; HUMANIORA; MEDICIN OCH HÄLSOVETENSKAP; HUMANIORA; MEDICAL AND HEALTH SCIENCES; HUMANITIES; Evidence; randomized controlled trials; observational studies; systematic reviews; meta-analysis; methodology; process assessment; outcome assessment; medical care; randomization; evidence-based medicine; selection bias; philosophy of medicine; philosophy of science; mechanisms; quality of evidence; animal studies; treatment effect; causation by absence; medical technology; Philosophy; Filosofi;

    Sammanfattning : This thesis examines philosophical controversies surrounding the evaluation of medical treatments, with a focus on the evidential roles of randomised trials and mechanisms in Evidence-Based Medicine. Current 'best practice' usually involves excluding non-randomised trial evidence from systematic reviews in cases where randomised trials are available for inclusion in the reviews. LÄS MER

  3. 3. Daily life after stroke in elderly people. Evaluation of stroke unit care focusing on daily activities, resource use and costs, assistive devices and health-related quality of life

    Författare :Gunilla Gosman-Hedström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Stroke unit; randomization; longitudinal study; resource use and cost; informal care; elderly; occupational therapy; daily activities; Functional Independence Measure; construct validity; assistive devices; housing modifications; health-related quality of life;

    Sammanfattning : Aims: The overall aims of this thesis were: a) to compare stroke unit (SU) care and its continuum with care on general wards (GW) for elderly patients, concerning resource use and costs for care and rehabilitation focusing on assistive technology in a one-year follow-up and, b) to explore the use and cost of assistive devices (ADs), ability in daily activities and self-rated health-related quality of life (HRQL) longitudinally.Methods: Two hundred and forty-nine persons >70 years were followed in a randomized, prospective study evaluating SU care after acute stroke. LÄS MER

  4. 4. Reactive Concurrent Data Structures and Algorithms for Synchronization

    Författare :Phuong Ha; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; non-blocking; reactive; multi-word atomic primitives; online algorithms; shared memory; concurrent data structures; distributed data structures; randomization; online financial problems; synchronization; spin-locks;

    Sammanfattning : Parallelism plays a significant role in high-performance computing systems, from large clusters of computers to chip-multithreading (CMT) processors. Performance of the parallel systems comes not only from concurrently runningmore processing hardware but also from utilizing the hardware efficiently. LÄS MER

  5. 5. Engineering Competitive and Query-Optimal Minimal-Adaptive Randomized Group Testing Strategies

    Författare :Muhammad Azam Sheikh; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; learning by queries; combinatorial search; competitive ratio; randomization; pooling design; group testing; linear program;

    Sammanfattning : Suppose that given is a collection of $n$ elements where $d$ of them are \emph{defective}. We can query an arbitrarily chosen subset of elements which returns Yes if the subset contains at least one defective and No if the subset is free of defectives. The problem of group testing is to identify the defectives with a minimum number of such queries. LÄS MER