Sökning: "dose escalation study"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden dose escalation study.
1. Model-Based Optimization of Clinical Trial Designs
Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER
2. CT Urography : Efforts to Reduce the Radiation Dose
Sammanfattning : Computed tomography urography (CTU) is today the imaging method used to investigate patients with suspected urinary tract malignancy, replacing the old imaging method intravenous pyelography (IVP) about a decade ago. The downside of this shift was that the effective radiation dose to the examined patient was eight times higher for CTU compared to IVP. LÄS MER
3. Dose Escalation with High Dose Rate Brachytherapy or Protons in Curative Radiotherapy of Prostate Cancer
Sammanfattning : The aim of the thesis was to study the outcome and side effects after dose-escalated radiotherapy with high dose rate brachytherapy (HDR-BT) or proton beam therapy (PBT) boost in prostate cancer.The first cohorts of men in Sweden treated with either HDR-BT or PBT in combination with conventional photon beam therapy (2 Gray (Gy) fractions to 50 Gy) were analysed. LÄS MER
4. Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer
Sammanfattning : Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. LÄS MER
5. Radiotherapy in advanced head and neck cancer
Sammanfattning : Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the patient both due to the tumour itself but also the treatment can be associated with side effects impairing quality of life. LÄS MER