Sökning: "Cisplatin"

Visar resultat 6 - 10 av 119 avhandlingar innehållade ordet Cisplatin.

  1. 6. Cisplatin : a platinum-containing antineoplastic drug : perspectives on analytical chemistry and prevention of ototoxicity

    Författare :Pernilla Videhult Pierre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cisplatin;

    Sammanfattning : The platinum-containing drug cisplatin plays a key role in the curative and palliative treatment of many solid malignancies. Unfortunately, the treatment can lead to sensorineural hearing loss, which limits the use of the drug. LÄS MER

  3. 7. Signaling pathways and novel genetic factors involved in modulation of cisplatin response in C. elegans

    Författare :Dorota Raj; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C. elegans; cisplatin; cancer; stress; immunity; post-mitotic; tail-anchored proteins;

    Sammanfattning : Cancer is a major cause of mortality throughout the world. Despite the effort of the scientific community, plenty remains to understand about the biology or genetics of cancer. In solid tumors often as many as 90-99% of all cells are non-dividing. LÄS MER

  4. 8. Influence of cisplatin on RNA structure in solution Escherichia coli tRNA(Ala) and human Wnt-5a 3' UTR model system studies

    Författare :Pal Papsai; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemi; metabolism; Proteins; enzymology; Proteiner; enzymologi; Metabolism; Biochemistry; Naturvetenskap; Natural science; tRNA.; siRNA; probing RNA structure in solution; alanyl-tRNA synthetase; cisplatin;

    Sammanfattning : RNA molecules in the cellular environment have several important functions. In many cases, proper RNA function is intimately linked to proper three-dimensional structure of the molecule. Thus, it seems reasonable to assume that structural changes caused by external influence can strongly inhibit important cellular functions maintained by RNAs. LÄS MER

  5. 9. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance

    Författare :Andreas Tyler; Kjell Grankvist; Simon Ekman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin resistance; exosomes; gb3; HSP70; the Bcl-2 family; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi; onkologi; Oncology;

    Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER

  7. 10. Manipulation of potassium ion fluxes to induce apoptosis in lung cancer cells

    Författare :Britta Andersson; Kjell Grankvist; Parviz Behnam-Motlagh; Roger Henriksson; Ola Brodin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; Cisplatin; Intracellular K content; Mesothelioma; Na K ATPase pump; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Apoptosis is a special form of cell death that if non-functional may lead to diseases such as cancer. A reduction of the intracellular potassium ion (K+) content is necessary for activating enzymes important for the execution of apoptosis. LÄS MER