Sökning: "Cisplatin"

Visar resultat 11 - 15 av 119 avhandlingar innehållade ordet Cisplatin.

1. 11. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

   Författare :Christopher Polonyi; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

   Sammanfattning : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. LÄS MER

3. 12. Reactions of Model and Anticancer Active Platinum(IV/II) Complexes - A Kinetic and Mechanistic Study

   Författare :Kelemu Lemma; Kemiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Model Pt II complexes; Anticancer active Pt IV compounds; Cisplatin; Rescue agents; L-Ascorbic acid; Thiol; Substitution; Kinetics and mechanism; Electron transfer; Inorganic chemistry; Oorganisk kemi;

   Sammanfattning : In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic acid and substitution reactions of cisplatin and model Pt(II) complexes with S-donor nucleophiles (rescue agents) have been investigated using stopped-flow and UV/VIS spectrophotometry. Glutathione (GSH) reduction of the anticancer active Pt(IV) compounds t- and c-[PtCl4(cha)(NH3)] (cha = cyclohexylamine), t-[PtCl4(thiazole)(NH3)] and c-[PtCl4(NH3)2] at 25 oC was observed to be very fast. LÄS MER

4. 13. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans

   Författare :Balasubramanian Natarajan; Peter Naredi; Richard Padgett; Umeå universitet; []
   Nyckelord :Insulin; C. elegans; ASNA1; Cisplatin; GRP94; unfolded protein response; SMN1; Developmental Biology; miljömedicinsk utvecklingsbiologi;

   Sammanfattning : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. LÄS MER

5. 14. PREDICTIVE AND PROGNOSTIC MARKERS IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

   Författare :Eva Henriksson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CCND1; cyclin D1; head and neck cancer; cisplatin; TP53; cell proliferation parameters; squamous cell carcinoma; predictive marker;

   Sammanfattning : Survival of patients with locally advanced head and neck squamous cell cancer(HNSCC)is poor, with an overall survival < 50%, despite diagnostic and therapeutic advances. The identification of prognostic and predictive markers could help optimizing treatment. LÄS MER

7. 15. Combined chemotherapy and immunotherapy against experimental malignant brain tumors

   Författare :Sara Fritzell; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin; Glioma; GM-CSF; IFN-gamma; IL-7; Immunotherapy; Intratumoral chemotherapy; Temozolomide;

   Sammanfattning : Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. LÄS MER