Sökning: "Cisplatin"

Visar resultat 16 - 20 av 119 avhandlingar innehållade ordet Cisplatin.

  1. 16. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

    Författare :Hanna Hedman; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

    Sammanfattning : To ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. LÄS MER

  3. 17. Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention

    Författare :Andreas Ekborn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cisplatin; ototoxicity; pharmacokinetics; monohydrated complex of cisplatin; protection;

    Sammanfattning : Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. LÄS MER

  4. 18. Bacterial toxins for cancer treatment

    Författare :David Johansson; Parviz Behnam-Motlagh; Kjell Grankvist; Anders Johansson; Roger Henriksson; Bo Baldetorp; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha‐toxin; AC‐toxin; mesothelioma; lung cancer; glioma; breast cancer; caspases; MAP-Kinase; verotoxin‐1; cisplatin; apoptosis; Gb3; drug resistance; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. LÄS MER

  5. 19. Hyaluronan in malignant pleural mesothelioma with special reference to diagnosis, tumourbiology and prognosis

    Författare :Anders Thylén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant pleural mesothelioma; hyaluronan; prognosis; methods; immunohistochemistry; tumourvolume; chemotherapy; tirapazamine; cisplatin;

    Sammanfattning : Malignant pleural mesothelioma (MPM), the primary malignant tumour of the pleural cavity, is an uncommon and treatment resistant tumour. The prognosis is poor. In many, but not all cases the concentration of hyaluronan (Hya) is increased in pleural effusion. The clinical relevance of Hya in MPM is not clear. LÄS MER

  7. 20. Nucleic Acids as Drug Targets -Interactions of Platinum Complexes, Polyamines, and siRNA with DNA and RNA Models

    Författare :Margareta Hägerlöf; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kinetics; Kemi; Chemistry; AU-rich region; siRNA; Circular Dichroism; Polyamine; Modified Nucleoside; HPLC; Thermodynamic Stability; cisplatin; Hairpin; DNA and RNA conformation; RNA; DNA; Anticancer Drug; Platinum Complexes;

    Sammanfattning : Drugs targeting nucleic acids were studied in DNA and RNA model systems. The effects were investigated with respect to structural and thermodynamic influence, kinetics, and biological function. The drugs employed in this thesis were anticancer active platinum(II) complexes, polyamine derivatives, and siRNA. LÄS MER