Sökning: "Cisplatin"

Visar resultat 21 - 25 av 119 avhandlingar innehållade ordet Cisplatin.

  1. 21. Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects

    Författare :Marie-Louise Fjällskog; Morten Vatn; Uppsala universitet; []
    Nyckelord :Medical sciences; pancreatic tumors; somatostatin analogs; cisplatin; etoposide; somatostatin receptors; immunohistochemistry; tyrosine kinase receptors; platelet-derived growth factors receptors PDGFRs ; c-kit; epidermal growth factor receptor EGFR ; MEDICIN OCH VÅRD; alfa-interferon; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : We treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs. LÄS MER

  3. 22. Systematic Modular Approaches to Reveal DNA Damage Responses in Mammalian Cells

    Författare :J. Peter Svensson; Ingela Turesson; Jean Bourhis; Uppsala universitet; []
    Nyckelord :Molecular biology; gene expression profiling; DNA damage; network; cancer; ionizing radiation; cisplatin; Molekylärbiologi;

    Sammanfattning : Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genomic DNA. As a single double strand DNA break has the potential to kill the cell, mechanisms have evolved to detect and block propagation of the damage. LÄS MER

  4. 23. Prognostic and Predictive Factors in Bladder Cancer

    Författare :Tammer Hemdan; Per-Uno Malmström; Ulrika Segersten; Peter Boström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bladder cancer; BCG; cisplatin; STMN1; emmprin; survivin; CCTα; biomarker; immunohistochemistry; IHC; tissue microarray; TMA;

    Sammanfattning : Bladder cancer is a potentially curable malignancy; however in regards to the state of current therapy regimens, a plateau has been reached in both the non-muscle and muscle invasive types. To obtain effective treatment, and consequently a decreased mortality, it has become imperative to test and understand aspects affecting therapy response. LÄS MER

  5. 24. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Författare :Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Sammanfattning :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER

  7. 25. Cationic Interactions with Nucleic Acids With Focus on Anticancer Active Platinum(II) Complexes

    Författare :Åse Sykfont Snygg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; in-line cleavage; Cisplatin; oxaliplatin; circular dichroism; DENSPM; polyamines; siRNA; pseudoknot; RNA; thermal melting; anticancer active Pt II complex; DNA;

    Sammanfattning : It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the ionic environment surrounding the polymer. LÄS MER