Sökning: "Paolo Carloni"

Hittade 2 avhandlingar innehållade orden Paolo Carloni.

1. 1. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA

   Författare :Johan Raber; David van der Spoel; Paolo Carloni; Uppsala universitet; []
   Nyckelord :Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

   Sammanfattning : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. LÄS MER

3. 2. Voltage sensor activation and modulation in ion channels

   Författare :Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

   Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER