Sökning: "Metallome"

Hittade 3 avhandlingar innehållade ordet Metallome.

  1. 1. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

    Författare :Yvonne Nygren; Erik Björn; Knut Irgum; Bente Gammelgaard; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. LÄS MER

  3. 2. Neutrophils versus Pathogenic Fungi : through the magnifying glass of nutritional immunity

    Författare :Maria Joanna Niemiec; Constantin F. Urban; Bernhard Hube; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; Candida albicans; nutritional immunity; metallome; Zn; Fe;

    Sammanfattning : Neutrophils are among the first white blood cells recruited to the site of infection once microbial pathogens enter the host organism. At site, they perform a well-orchestrated chain of processes that aims to kill the microbial invader. Most prominent, neutrophils engulf microbes to inactivate them intracellularly, a process called phagocytosis. LÄS MER

  4. 3. Effects of pharmaceutical modulation of protein aggregation on lifespan in Caenorhabditis elegans

    Författare :Ida Klang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aging is accompanied by a disruption in various homeostatic networks including those devoted to maintaining protein conformation and integrity. Collectively this maintenance is referred to protein homeostasis or proteostasis. LÄS MER