Sökning: "aquation"

Hittade 1 avhandling innehållade ordet aquation.

1. 1. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA

   Författare :Johan Raber; David van der Spoel; Paolo Carloni; Uppsala universitet; []
   Nyckelord :Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

   Sammanfattning : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. LÄS MER