Sökning: "uptake inhibitors"

Visar resultat 1 - 5 av 95 avhandlingar innehållade orden uptake inhibitors.

1. 1. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors

   Författare :Tiago Bozzola; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic Acid; antibacterial agents; Medicinal Chemistry; Synthesis; uptake inhibitors;

   Sammanfattning : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. LÄS MER

3. 2. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications

   Författare :John Stegmayr; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectins; inhibitors; evaluation assays; cell culture; idiopathic pulmonary fibrosis; synthetic small-molecule galectin inhibitors; plant-derived polysaccharides;

   Sammanfattning : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. LÄS MER

4. 3. Antibiotic uptake in Gram-negative bacteria

   Författare :Claudio Muheim; Daniel Daley; Jean-Marie Pagès; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Gram-negative bacteria; Antibiotic uptake; Outer membrane; Lipopolysaccharide; Biochemistry; biokemi;

   Sammanfattning : The increasing emergence and spread of antibiotic-resistant bacteria is a serious threat to public health. Of particular concern are Gram-negative bacteria such as Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae or Pseudomonas aeruginosa. LÄS MER

5. 4. Towards membrane engineering as a tool in cell factory design: A case study on acetic acid tolerance in Saccharomyces cerevisiae

   Författare :Lina Lindahl; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; butanol; inhibitors; lipidomics; Key words: Lignocellulose; Zygosaccharomyces bailii; molecular dynamics simulations; membrane permeability; carbon-14 uptake; ethanol; robustness;

   Sammanfattning : The sustainable production of fuels, chemicals, and materials using renewable resources is a necessity if we are to reduce our ecological footprint and the rate of climate change. Lignocellulosic biomass, the major constituent of plant cell walls, is a renewable raw material with great potential due to its high abundance. LÄS MER

7. 5. Selective serotonin re-uptake inhibitors in the environment : Effects of citalopram on fish behaviour

   Författare :Martin Kellner; Håkan Olsén; Inger Porsch-Hällström; Magnus Breitholtz; Södertörns högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Citalopram; SSRI; stickleback; Baltic; behaviour; fish; feeding; anxiety; boldness; serotonin; development; Storspigg; serotonin; östersjön; SSRI; läkemedel; miljö; citalopram; ätbeteende; beteende; utveckling; Environmental Studies; Miljövetenskapliga studier; Östersjö- och Östeuropaforskning; Baltic and East European studies;

   Sammanfattning : Selective serotonin re-uptake inhibitors (SSRIs) are a class of anxiolytic and anti-depressant drugs. SSRIs act on the evolutionarily ancient serotonergic system which is virtually identical throughout the vertebrate phylum. LÄS MER