Sökning: "membrane permeability"
Visar resultat 1 - 5 av 143 avhandlingar innehållade orden membrane permeability.
1. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients
Sammanfattning : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. LÄS MER
2. Free Volume and Mesopores in Polymer Nanocomposites
Sammanfattning : The free volume in polymers is coupled to several important physical properties, such as density, viscosity and gas diffusivity. The physical properties of polymers close to a solid surface have been shown to be significantly perturbed as compared to their bulk state. LÄS MER
3. Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2
Sammanfattning : Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which proteins and carbohydrates are anchored and exert their function. LÄS MER
4. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition
Sammanfattning : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. LÄS MER
5. Membrane Fluidity Regulation: From C. elegans to mammalian cells
Sammanfattning : Biological membranes are primarily an assembly of lipids and proteins. Collectively, these constituents within a phospholipid bilayer determine the physical membrane properties such as fluidity, viscosity, thickness, packing and permeability. Maintenance of membrane properties within acceptable margins, i.e. LÄS MER