Sökning: "protein disease"
Visar resultat 21 - 25 av 2666 avhandlingar innehållade orden protein disease.
21. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes
Sammanfattning : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. LÄS MER
22. Neuroinflammation in Alzheimer's disease : Focus on NF-κB and C/EBP transcription factors
Sammanfattning : Alzheimer's disease (AD) is the most common form of dementia among elderly. The disease is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic neuroinflammation. LÄS MER
23. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease
Sammanfattning : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). LÄS MER
24. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology
Sammanfattning : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. LÄS MER
25. Array-based identification of disease-associated proteins
Sammanfattning : To increase our understanding of the human body in both health and disease, proteins can be studied in samples such as plasma and serum to provide a molecular profile of the physiological status. In the work presented in this thesis, array-based methods were used to study associations of protein and autoantibody profiles with disease. LÄS MER