Sökning: "protein disease"
Visar resultat 16 - 20 av 2666 avhandlingar innehållade orden protein disease.
16. Protein folding studies of human superoxide dismutase and ALS associated mutants
Sammanfattning : Proteins are among the most abundant biological macromolecules. The cellular machinery is coupled to exact structural shape and properties of the more than 100 000 different proteins. Still, proteins can sometimes completely change their character and as a result trigger neuro degenerative disease. LÄS MER
17. Membrane mediated aggregation of amyloid-β protein : a potential key event in Alzheimer's disease
Sammanfattning : The pathogenesis of Alzheimer’s disease (AD), the most common senile dementia, is a complex process. A crucial event in AD is the aggregation of amyloid-β protein (Aβ), a cleavage product from the Amyloid Precursor Protein (APP). LÄS MER
18. Amyloid Beta – Biotherapy Target and Biotechnological Tool
Sammanfattning : Alzheimer’s disease is a progressive neurodegenerative disease characterized primarily by memory impairment and cognitive decline. As of 2020, an estimated 50 million people suffer from Alzheimer’s disease or related dementia and no disease-modifying treatment options are yet approved for clinical practice. LÄS MER
19. Susceptibility genes in conformational diseases
Sammanfattning : Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent ... LÄS MER
20. Vitamin K-dependent protein S - studies of synthesis, structure and function
Sammanfattning : This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. LÄS MER