Sökning: "Neurosciences"

Visar resultat 1 - 5 av 511 avhandlingar innehållade ordet Neurosciences.

  1. 1. Microglial cells in Neurodegenerative Diseases. The Role of Galectin-3

    Författare :Antonio Boza Serrano; Neuroinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; neurosciences; microglia; Galectin-3; Alzheimer disease; Parkinson disease; innate immune system; TLR4; TREM2;

    Sammanfattning : Today, dementia such as, Alzheimer’s disease (AD), vascular diseases and motor neurodegenerative diseases, such as Parkinson’s disease (PD), represent a major public health problem. For instance, PD affect to more than 10 million people worldwide and almost 50 million people are affected by dementia. LÄS MER

  3. 2. GDNF and alpha-synuclein in nigrostriatal degeneration

    Författare :Maria Chermenina; Ingrid Strömberg; Guido Nikkhah; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; GDNF; ventral mesencephalon; lateral ganglionic eminence; alpha-synuclein; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Parkinson’s disease is a common neurological disorder with a complex etiology. The disease is characterized by a progressive loss of dopaminergic cells in the substantia nigra, which leads to motor function and sometimes cognitive function disabilities. LÄS MER

  4. 3. Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models

    Författare :Henrik Gezelius; Klas Kullander; Ted Ebendal; Martyn Goulding; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acetyl choline; central nervous system; central pattern generator; Cre recombinase; development; genetic screen; glutamate; interneuron; motor neuron; mouse; mouse genetics; movement; network; neuronal network; nicotinic receptors; physiology; Renshaw cell; rhythm; spinal cord; transmitter; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi; Neurophysiology; Neurofysiologi; Neurobiology; Neurobiologi; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Spinal neurons are important in several aspects motor control. For example, the neurons essential for locomotor movements reside in the ventral spinal cord. In this thesis, different motor control functions are being related to neuronal populations defined by their common expression of a gene. LÄS MER

  5. 4. Gene Expression in the Brains of Two Lines of Chicken Divergently Selected for High and Low Body Weight

    Författare :Sojeong Ka; Finn Hallböök; Tom Porter; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chicken; juvenile body weight; divergent selection; gene expression; DNA microarray; quantitiative RT-PCR; hypothalamus; neural plasticity; melanocortin system; endogenous retrovirus; carnitine palmitoyltransferase-1b; Neurobiology; Neurobiologi; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Artificial divergent selection of chickens for high and low body weight at 8 weeks of age has produced two lines: the high (HWS) and low (LWS) body weight chicken lines. In addition to the difference in body weight, the lines show extreme differences in feeding behaviour and body composition. LÄS MER

  7. 5. Dysfunction in the nigrostriatal system : effects of L-DOPA and GDNF

    Författare :Nina Nevalainen; Ingrid Strömberg; Nancy Zahniser; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; L-DOPA; dyskinesia; GDNF; dopamine; glutamate; serotonin; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Parkinson’s disease is a common neurodegenerative disorder caused by nigrostriatal dopamine loss, with motor deficiencies as the primary outcome. To increase the striatal dopamine content, patients are treated with 3,4-dihydroxyphenyl-l-alanine (l-DOPA). LÄS MER