Sökning: "Protofibrils"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet Protofibrils.

  1. 1. Cellular responses to amyloid-beta protofibrils Focus on astrocytes, extracellular vesicles and antibody treatment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Elisabeth Nikitidou; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid-beta; Protofibrils; Astrocytes; Extracellular vesicles; Antibody; Neurons; Degradation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease (AD) is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention has been given to the glial cells. LÄS MER

  2. 2. Amyloid-β Protofibrils in Alzheimer´s Disease Focus on Antibodies, Inflammation and Astrocytes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sofia Söllvander; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. LÄS MER

  3. 3. Amyloid-β Protofibril Formation and Neurotoxicity Implications for Alzheimer’s Disease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ann-Sofi Johansson; Uppsala universitet.; [2007]
    Nyckelord :Neurosciences; Amyloid-β; Neurotoxicity; Aggregation; Protofibrils; Alzheimer s disease; Neurovetenskap;

    Sammanfattning : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). LÄS MER

  4. 4. Aβ Conformation Dependent Antibodies and Alzheimer's Disease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Dag Sehlin; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; protofibrils; conformation; monoclonal antibody; ELISA; MEDICINE; MEDICIN; Geriatrics; Geriatrik;

    Sammanfattning : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. LÄS MER

  5. 5. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Lord; Uppsala universitet.; [2009]
    Nyckelord :Geriatrics; geriatrik;

    Sammanfattning : The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils, in the pathogenesis. LÄS MER