Sökning: "Neurochemistry with Molecular Neurobiology"
Visar resultat 1 - 5 av 68 avhandlingar innehållade orden Neurochemistry with Molecular Neurobiology.
1. Oligonucleotide Complexes with Cell-Penetrating Peptides Structure, Binding, Translocation and Flux in Lipid Membranes
Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm UniversitySammanfattning : The ability of cell-penetrating peptides to cross plasma membranes has been explored for various applications, including the delivery of bioactive molecules to inhibit disease-causing cellular processes. The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. LÄS MER
2. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations
Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm UniversitySammanfattning : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. LÄS MER
3. Kinetic assays for RNA-cleaving deoxyribozymes and other nucleases
Detta är en avhandling från Stockholm : Department of NeurochemistrySammanfattning : In this thesis two different assays for real-time RNA-cleaving deoxyribozyme and general nuclease kinetics are presented. Previous publications on nuclease kinetic assays have been riddled with drawbacks of labeling, discontinuity, cost etc. LÄS MER
4. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects
Detta är en avhandling från Stockholm : Department of NeurochemistrySammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER
5. In-silico design of peptide-based transfection systems, in-vitro validation, and up-take pathways investigation
Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm UniversitySammanfattning : Cell-penetrating peptide-based transfection systems (PBTS) are a promising group of drug delivery vectors. Cell-penetrating peptides (CPPs) are short cationic peptides that are able of transporting cell non-permeant cargos into different cell types. LÄS MER
