Sökning: "myeloid dendritic cells"

Visar resultat 6 - 10 av 50 avhandlingar innehållade orden myeloid dendritic cells.

  1. 6. Functions and memory features of adaptive- and innate immune cells in physiological and inflammatory settings

    Författare :Gintare Lasaviciute; Eva Sverremark-Ekström; Silke Appel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Innate immune memory; Limosilactobacillus reuteri; dendritic cells; lymphocytes; cytokines; immunological memory; intestinal epithelial cells; chemotherapy; bone marrow; secondary lymphoid organs; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The immune system is a complex but well-regulated network which cooperates with the microbiota to maintain optimal homeostasis under physiological settings. A number of factors display the capacity to alter the immune system and thus microbiota crosstalk including host genetics, diet, environmental influences and drugs such as antibiotics or chemotherapeutic agents. LÄS MER

  3. 7. Regulation of B cell function by plasmacytoid dendritic cells

    Författare :Cornelia Gujer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cell;

    Sammanfattning : Dendritic cells (DCs) are early sentinels of pathogen exposure and central in the initiation and orchestration of adaptive immune responses. Apart from the prominent role of DCs in the activation of T cells, DCs have been shown to influence humoral B cell mediated responses. LÄS MER

  4. 8. Mechanisms of leukemia-induced immunosuppression

    Författare :Johan Aurelius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Sammanfattning : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. LÄS MER

  5. 9. Initiation of Autoimmunity in Experimental Autoimmune Encephalomyelitis

    Författare :Magnus Isaksson; Anna Lobell; Olle Kämpe; William Agace; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Cytokines; Dendritic cells; DNA vaccination; EAE; Innate immunity; T helper cells; Toll-like receptors; Type I interferons; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The events that trigger an autoimmune disease remain largely unknown. To study these events animal models are necessary because symptoms of autoimmune diseases are preceded by a long asymptomatic period in humans. LÄS MER

  7. 10. Studies of the tumor microenvironment : Local and systemic effects exerted by the cross-talk between tumor and stroma cells in pancreatic cancer

    Författare :Vegard Tjomsland; Marie Larsson; Arne Östman; Linköpings universitet; []
    Nyckelord :Pancreatic cancer; cancer associated fibroblasts; dendritic cells; IL-1alpha; tumor microenvironment; inflammation; bukspottkörtelcancer; Bukspyttkjertel kreft; MEDICINE; MEDICIN;

    Sammanfattning : Pancreatic cancer is one of the most lethal cancers and despite all research efforts the last 50 years, there are still no effective therapy for this terrible disease. Until quite recently most research in the field of pancreatic duct adenocarcinoma (PDAC) was focused on the tumor cells and mechanisms essential for their proliferation and survival. LÄS MER