Sökning: "Anna Lobell"
Hittade 5 avhandlingar innehållade orden Anna Lobell.
Sammanfattning : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. LÄS MER
Sammanfattning : The studies presented in this thesis focus on human and canine models for autoimmune disease, with the main aim to gain new knowledge about disease mechanisms and to further evaluate the dog as a model for autoimmune disease. Autoimmune Polyendocrine Syndrome type 1 (APS-1) is a hereditary human multiorgan disease caused by mutations in the autoimmune regulator (AIRE) gene. LÄS MER
Sammanfattning : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. LÄS MER
Sammanfattning : The events that trigger an autoimmune disease remain largely unknown. To study these events animal models are necessary because symptoms of autoimmune diseases are preceded by a long asymptomatic period in humans. LÄS MER
Sammanfattning : Human autoimmune diseases are hallmarked by inappropriate loss-of-tolerance and self-attacking response of the immune system. Studies included in this thesis are focusing on the implication and functional impact of genetic factors in three autoimmune diseases rheumatoid arthritis (RA), asthma, and systemic lupus erythematosus (SLE). LÄS MER