Sökning: "DNA vaccination"
Visar resultat 1 - 5 av 90 avhandlingar innehållade orden DNA vaccination.
1. DNA vaccines and bacterial DNA in immunity
Sammanfattning : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. LÄS MER
2. Suppressive DNA vaccination in experimental autoimmune encephalomyelitis
Sammanfattning : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. LÄS MER
3. Enhancing T cell mediated immunity in DNA vaccination
Sammanfattning : For centuries infectious diseases have been one of the main causes of death in the world. With the invention of vaccine technology 200 years ago, we have been able to impede and even eradicate several dangerous pathogens. LÄS MER
4. Studies in DNA immunization
Sammanfattning : This thesis describes investigations and developments of DNA immunization techniques, which were applied in the study of two different pathogens; HIV-1 and Chlamydia pneumoniae. DNA vaccines, i.e. naked plasmid DNA encoding an antigen, represent a novel strategy for generating protective immunity against several infectious diseases. LÄS MER
5. Vaccination in gastrointestinal cancer
Sammanfattning : Advances in immunology have increased the possibility to develop therapeutic cancer vaccines (TCV), as a complementary approach to standard treatment. The goal of a successful cancer vaccine is to induce a potent long-lasting immune response against the tumour with limited toxicity on normal cells. LÄS MER