Sökning: "metabolites"

Visar resultat 6 - 10 av 763 avhandlingar innehållade ordet metabolites.

1. 6. Pharmacokinetics - Effect Relations of Glibenclamide and its Metabolites in Humans

   Författare :Tony S Rydberg; Institutionen för hälsovetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal insufficiency.; insulin; glucose; non-insulin dependent; diabetes mellitus; pharmacodynamic modelling; pharmacodynamics; pharmaco-kinetics; HPLC method; Glibenclamide; sulphonylurea; metabolites; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Glibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). LÄS MER

3. 7. Secondary Metabolites from Mozambican Plants

   Författare :Julião Monjane; Centrum för analys och syntes; []
   Nyckelord :Secondary metabolites; Mozambique; Medicinal plants; Isolation; Structural elucidation; Antileishmanial activity;

   Sammanfattning : Products derived from different natural sources have been used for thousands of years by human beings for their everyday needs. Out of these natural sources, plants were the most affordable. Plant-derived products were used for shelter, food, and as medicines. LÄS MER

4. 8. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

   Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER

5. 9. Toxicologically important DDT metabolites : Synthesis, enantioselective analysis and kinetics

   Författare :Tatiana Cantillana; Åke Bergman; Peter Sundin; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; o; p -DDD; 3-Methylsulfonyl-DDE; adrenocorticolytic compounds; chiral; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

   Sammanfattning : DDT was extensively and globally used as a pesticide in agriculture and for malaria vector control from the 1940’s until the 1970’s. Due to its heavy use, DDT became ubiquitously distributed throughout the environment. DDT and several DDT metabolites are persistent organic pollutants. LÄS MER

7. 10. Polyurethane - occupational exposure, biomarkers and symptoms

   Författare :Margareta Littorin; Avdelningen för arbets- och miljömedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spray; polyurethane; nose; metabolites; lung function ; lower airways; inflammation; heat; glue; genetic polymorphism; di isocyanate; Antibodies; biomarkers; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin; symptoms;

   Sammanfattning : Isocyanates may cause occupational asthma, rhinitis, and hypersensitivity pneumonitis. However, the mechanisms behind initiation of the disorders and the relations between exposure and effect are insufficiently elucidated. Means to biomonitor exposure and risk would be valuable. LÄS MER