Sökning: "sulphonylurea"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet sulphonylurea.

  1. 1. Pharmacoepidemiologic Studies of Diabetes Mellitus - with special reference to - Glucose Control and Prognosis of Type 2 Diabetes

    Författare :Jonny Olsson; Samhällsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; cohort study; longitudinal study; cross-sectional study; mortality; diabetes mellitus; Pharmacoepidemiology; prevalence; type 2 diabetes; diabetes costs; short-term sick-leave; premature retirement; production losses; inpatient care; glycaemic control; fasting blood glucose; oral antihyperglycaemic agents; sulphonylurea; metformin; insulin; combination treatment; drug utilization; prescribed daily doses; safety; effectiveness; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : The efficacy and safety of antihyperglycaemic drugs have been evaluated in one American and one British randomized clinical trial, which have given contradictory results. The positive results of the latter may be more convincing as it included a greater number of patients and as its duration was longer. LÄS MER

  3. 2. Pharmacokinetics - Effect Relations of Glibenclamide and its Metabolites in Humans

    Författare :Tony S Rydberg; Institutionen för hälsovetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal insufficiency.; insulin; glucose; non-insulin dependent; diabetes mellitus; pharmacodynamic modelling; pharmacodynamics; pharmaco-kinetics; HPLC method; Glibenclamide; sulphonylurea; metabolites; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Glibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). LÄS MER

  4. 3. Combined sulphonylurea and insulin treatment for type 2 diabetes mellitus : metabolic and electrophysiological studies

    Författare :Lena Landstedt-Hallin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :type 2 diabetes; sulphonylurea; secondary failure; insulin; combined therapy; hypoglycaemia; glucagon; QT interval;

    Sammanfattning : Type 2 diabetes is a prevalent disorder characterized by elevated blood glucose levels and associated with increased morbidity from micro- and macrovascular complications. Lowering of blood glucose has been shown to reduce the incidence of such complications. LÄS MER

  5. 4. On the pharmacodynamics, pharmacokinetics and metabolism of sulphonylurea and its metabolites - with special reference to glibenclamide

    Författare :Anders Jönsson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; secreting systems; diabetology; Endocrinology; diabetologi;

    Sammanfattning : The pharmacodynamics (PD), pharmacokinetics (PK) and metabolism of the sulphonylurea(SU) and its metabolites (M1 and M2) , and of another SU, glipizide (Gz) were studied in diabetes patients and healthy volunteers. In one study Caucasians and Chinese were compared. LÄS MER

  7. 5. Secondary drug failure in non insulin dependent diabetes : on causes and aspects of treatment

    Författare :Per Clauson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Non insulin dependent diabetes; treatment failure; insulin; sulphonylurea; insulin-like growth factor-I; insulin-like growth factor bindingprotein-1; insulin secretion; insulin sensitivity; insulin absorption.;

    Sammanfattning : Non Insulin Dependent Diabetes (NIDDM) represents a major health problem with increased risk of atherosclerotic disease and early death. The grave consequences of NIDDM are partly due to inadequate and insufficient treatment. The purpose of the present study was to study the causes of treatment failure and evaluate new strategies of treatment. LÄS MER