Sökning: "LC-MS MS"

Visar resultat 1 - 5 av 183 avhandlingar innehållade orden LC-MS MS.

  1. 1. Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics

    Författare :Albert Elmsjö; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Metabolomics; NMR; LC-MS; HILIC; UHPLC; Q-ToF; selectivity; co-feature ratio; method evaluation; data evaluation; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. LÄS MER

  2. 2. Damsel in distress – metabolomics as a novel tool to investigate the effects of wastewater exposure on damselfly larvae

    Författare :Jana Späth; Malin L. Nording; Jerker Fick; Stina Jansson; Tuulia Hyötyläinen; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; biomarkers; ecotoxicology; invertebrates; GC-MS; LC-MS; LC-MS MS; metabolomics; micropollutants; pharmaceuticals; risk assessment; ekotoxikologi; Ecotoxicology; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Aquatic organisms, such as aquatic invertebrates, are exposed to anthropogenic pollutants through their environment. These pollutants, despite their low levels, can adversely affect exposed individuals or even entire ecosystems, especially when present in complex mixtures. LÄS MER

  3. 3. Analysis of Metabolites in Complex Biological Samples Using LC/MS and Multivariate Data Analysis : Metabolic Fingerprinting and Detection of Biomarkers

    Författare :Helena Idborg; Sven Jacobsson; Per-Olof Edlund; Jonas Bergquist; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Metabonomics; Metabolic Fingerprinting; Drug Metabolism; Biomarkers; Human Plasma; Rat Urine; LC MS; ZIC-HILIC; UPLC; UHPLC; ToF; Curve Resolution; Peak Detection; Pattern Recognition; Classification; PCA; PLS; PARAFAC; N-PLS; Data Fusion; Hierarchical Modeling; Batch modeling; Data Concatenation; Breast Cancer; Phospholipidosis; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : To facilitate early diagnosis of diseases and elucidation of the processes involved in their development and progression, various specific compounds or ‘biomarkers’ are often monitored. The first step is to decide which compounds to analyze. LÄS MER

  4. 4. New strategies and tools for optimizing LC-MS data processing in metabolomics

    Författare :Mattias Eliasson; Johan Trygg; Björn Grung; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  5. 5. Diagnosis of acute and chronic enteric fever using metabolomics

    Författare :Elin Näsström; Henrik Antti; Anders Johansson; Peter Spégel; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Enteric fever; Salmonella; chronic carriers; metabolomics; diagnosis; biomarkers; multivariate data analysis; GCxGC-MS; GC-MS; LC-MS;

    Sammanfattning : Enteric (or typhoid) fever is a systemic infection mainly caused by Salmonella Typhi and Salmonella Paratyphi A. The disease is common in areas with poor water quality and insufficient sanitation. Humans are the only reservoir for transmission of the disease. LÄS MER