Sökning: "asymmetric additions"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden asymmetric additions.

  1. 1. Development and application of new chiral -amino alcohols in synthesis and catalysis Use of 2-azanorboryl-3-methanols as common intermediates in synthesis and catalysis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Pedro Pinho; [2001]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Asymmetric synthesis; hetero-Diels-Alder reactions; chiral cyclopentyl-amines; chiral ligands and catalysts; amino alcohols; asymmetric reductions; ruthenium transfer hydrogenation; oxazaborolidines; asymmetric additions; dialkylzinc reagents; Kemi; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : The development and application of unnatural amino alcohols,prepared via hetero-Diels-Alder reactions,in synthesis and catalysis is described.The studies are concerned with the [i]scope of the hetero-Diels-Alder reaction and preparation of important intermediates in the synthesis of antiviral agents,[ii ]application of amino alcohols in the ruthenium transfer hydrogenation of ketones,[iii ]use of similar precursors in the in situ generation of oxazaborolidines for reduction of ketones,and [iv] development and application of new chiral auxiliaries for dialkylzinc additions to activated imines, respectively. LÄS MER

  2. 2. Organocopper compounds and iodotrimethylsilane in stereoselective conjugate additions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mikael Bergdahl; [1992]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organoccopper; stereoselective; 1.4 addition; TMSI; conjugate addition; iodotrimethylsilane; asymmetric; optical activity; halosilanes; chiral; copper reagerent;

    Sammanfattning : .... LÄS MER

  3. 3. Synthesis and evaluation of bicyclic 1,3-diols (BODOLs) as ligands for asymmetric catalysis

    Detta är en avhandling från Department of Organic Chemistry, Lund University

    Författare :Ian Sarvary; [2002]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; yeast reductions; supramolecular chemistry; diethylzinc; computation; structure of Ti-diolates; diol ligands; titanates; asymmetric catalysis; asymmetric synthesis;

    Sammanfattning : Several ligands based upon 2-substituted bicyclic[2.2.2]octane-2,6-diols (BODOLs) were synthesized and evaluated in two catalytic reactions: I) the Ti(IV)-mediated catecholborane asymmetric reduction of prochiral ketones and II) as catalysts in the asymmetric addition of diethylzinc to aromatic aldehydes. LÄS MER

  4. 4. Stereoselective Nucleophilic Additions to Aldehydes and Synthesis of α-Amino-β- Hydroxy-Esters

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Jakob Danielsson; Peter Somfai; Hans Adolfsson; Tobias Rein; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric induction; stereochemical models; Mukaiyama; polar Felkin-Anh; Cornforth-Evans; 1; 3-dipole; aziridine; cycloaddition; amino alcohol; carbonylation; Heck reaction; quaternary stereocenter;

    Sammanfattning : This thesis deals with the development of new reaction methodology as well as stereochemical investigations.The first part concerns the investigation of 1,2- and merged 1,2- and 1,3- asymmetric induction in Mukaiyama aldol additions to α-heteroatom and α,β- heteroatom substituted aldehydes respectively. LÄS MER

  5. 5. Developments in the Field of Aza-Diels-Alder Reactions, Catalytic Michael Additions and Automated Synthesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Stefan Modin; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Asymmetric synthesis; aza-Diels-Alder; Michael addition; Transfer hydrogenation; automated synthesis; Catalysis; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : The development of new aza-bicyclic structures with potential applications as ligands synthesised via an aza-Diels-Alder cycloaddition has been studied. The studies are concerning the i) development of large scale aza-Diels-Alder reaction, ii) development of a fast and simple route to bicyclic diamine ligands, iii) development of new aza-Diels-Alder adducts from different dienes, iv) development and application of bicyclic N,P ligands for catalytic Michael additions and v) development of robotized asymmetric transfer hydrogenation reactions. LÄS MER