Sökning: "lung diseases"

Visar resultat 11 - 15 av 255 avhandlingar innehållade orden lung diseases.

1. 11. Endothelin receptor changes during inflammation in the lung

   Författare :Bengt Granström; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Andningsorganen; Respiratory system; Upregulation; Smooth muscle cells; Smoking; Sephadex; Remodeling; Rat; mRNA; Human; ETB receptor; ETA receptor; Lung; Endothelin; Asthma bronchiale; Contraction;

   Sammanfattning : Endothelin-1 (ET-1) is an extremely potent smooth muscle spasmogen well known from the vascular system but also active within the airways. The importance of its proinflammatory and co-mitogenic properties has become increasingly evident, the endothelin system also having been shown to mimic the signal features of asthma, COPD and other pulmonary diseases. LÄS MER

3. 12. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

   Författare :Ann Tronde; Gerrit Borchard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Sammanfattning : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. LÄS MER

4. 13. Nanomaterials : respiratory and immunological effects following inhalation of engineered nanoparticles

   Författare :Åsa Gustafsson; Anders Bucht; Thomas Sandström; Johnny Lorentzen; Mikael Adner; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanoparticles; nanomaterials; inhalation; lung; metalloxides; immunologi; Immunology; Toxicology; toxikologi; lungmedicin; Lung Medicine; Occupational and Environmental Medicine; arbets- och miljömedicin; nanopartiklar; nanoparticles; nanotoxikologi; nanotoxicology;

   Sammanfattning : Background Nanotechnology is an important and promising field that can lead to improved environment and human health and contribute to a better social and economic development. Materials in nanoscale have unique physiochemical properties which allow for completely new technical applications. LÄS MER

5. 14. Chronic Obstructive Pulmonary Disease : Patients´ Perspectives, Impact of the Disease and Utilization of Spirometry

   Författare :Mats Arne; Margareta Emtner; Gunnar Boman; Staffan Janson; Claes-Göran Löfdahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic disease; chronic obstructive pulmonary disease; diabetes mellitus; diagnosis; health status; spirometry; physical activity; public health survey; qualitative method; quality of life; rheumatoid arthritis.; Lung diseases; Lungsjukdomar; Lungmedicin; Lung Medicine;

   Sammanfattning : The overall aim of this thesis was to describe subjects with chronic obstructive pulmonary disease (COPD) from different perspectives. Focus was on patients at the time of diagnosis, impact of the disease in comparison to other chronic diseases, factors associated with good health and quality of life (QoL), and diagnostic spirometry in clinical practice. LÄS MER

7. 15. Ozone and diesel exhaust : airway signaling, inflammation and pollutant interactions

   Författare :Jenny Bosson; Anders Blomberg; Thomas Sandström; Ellinor Ädelroth; John Balmes; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; air pollution; ozone; diesel exhaust; airway inflammation; asthma; immunohistochemistry; Lung diseases; Lungsjukdomar; lungmedicin; Lung Medicine;

   Sammanfattning : It is well established that air pollution has detrimental effects on both human health as well as the environment. Exposure to ozone and particulate matter pollution, is associated with an increase in cardiopulmonary mortality and morbidity. Asthmatics, elderly and children have been indicated as especially sensitive groups. LÄS MER