Sökning: "hypothalamus"

Visar resultat 11 - 15 av 151 avhandlingar innehållade ordet hypothalamus.

  1. 11. Genes implicated in the development of obesity and obesity-related disease

    Författare :Kajsa Lindell; Göteborgs universitet; []
    Nyckelord :obesity; adipose tissue; hypothalamus; leptin; leptin receptor; 5 untranslated region; hypertension; angiotensinogen; DNA microarray;

    Sammanfattning : Obesity is a major health problem because of its dramatic increase in prevalence and the association of obesity with type 2 diabetes, coronary heart disease, hypertension and stroke. Although mutations in certain genes have been shown to cause obesity, the molecular mechanisms underlying obesity and obesity-related disease are still largely unknown. LÄS MER

  3. 12. IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice

    Författare :Fredrik Anesten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6Rα; GLP-1; obesity; hypothalamus; brainstem; tanycytes; immunohistochemistry;

    Sammanfattning : It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ICV- injections, but not peripheral injections of IL-6, increases energy expenditure and decreases body fat in rodents. LÄS MER

  4. 13. Nitric oxide in central nervous structures associated with water balance and micturition

    Författare :Anders Nylén; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; spinal projections; True Blue; cystometry; circumventricular organs; paraventricular nucleus; supraoptic nucleus; NADPH diaphorase; immunohistochemistry; oxytocin; 8-arginine-vasopressin; hypothalamus; rat; micturition; nitric oxide; water balance; neuronal nitric oxide synthase; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The role of nitric oxide (NO) in the central control of water balance and micturition has not yet been established. In the present thesis, where female rats were used, neuronal NO synthase (nNOS) distribution was studied in structures of the central nervous system known to be associated with the above mentioned control. LÄS MER

  5. 14. Craniopharyngioma. Morbidity and Structural Changes in the Brain

    Författare :Sigríður Bára Fjalldal; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; craniopharyngioma; hypothalamus; hypothalamic obesity; metabolism; cognition; magnetic resonance imaging; diffusion tensor imaging; white matter lesions; morbidity; cardiovascular risk; craniofaryngiom; hypotalamus; hypotalamisk fetma; ämnesomsättning; kognition; magnetkameraundersökning; vitsubstansförändringar; dödlighet; hjärt-kärlsjukdomar;

    Sammanfattning : Hypothalamus (HT) is a brain structure which serves as a coordination center for several vital body functions. Craniopharyngioma (CP) is a pituitary tumor with high morbidity, primarily due to HT lesion. LÄS MER

  7. 15. Central and Peripheral Neuroendocrine Factors in Cancer-Associated Anorexia and Cachexia

    Författare :Jonathan R Burgos; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer anorexia-cachexia syndrome; inflammation; TSH receptor; cocaine- and amphetamine-regulated transcript; nesfatin-1; CRH; hypothalamus; brainstem; MCG101;

    Sammanfattning : Cancer anorexia-cachexia syndrome (CACS) develops in response to tumor-host biochemical interactions. A loss of appetite (anorexia) and increased metabolism results in a progressive wasting of adipose and skeletal muscle tissues (cachexia). LÄS MER