Sökning: "hypothalamus"

Visar resultat 21 - 25 av 151 avhandlingar innehållade ordet hypothalamus.

1. 21. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

   Författare :Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

   Sammanfattning : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. LÄS MER

3. 22. Studies of lipolysis and neuroendocrine rhythms in cluster headache

   Författare :Eva Laudon Meyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cluster headache; autonomic nervous system; hypothalamus; lipolysis; microdialysis;

   Sammanfattning : Cluster headache (CH) is characterised by excruciating, unilateral headache attacks, which in the episodic form appear in clusters for weeks or even months. The headache attacks are often accompanied by ipsilateral, cranial autonomic symptoms supporting a local peripheral sympathetic deficit and a parasympathetic discharge. LÄS MER

4. 23. Hypothalamic neuronal circuits involved in the regulation of food intake and body weight : histochemical studies in lean rats and obese mutant mice

   Författare :Matilda Bäckberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AGRP; arcuate nucleus; BBB; CART; GABA; GABA receptors; immunohistochemistry; in situ hybridization; hypothalamus; LHA; leptin; MCH; NPY; orexin; POMC; tubby;

   Sammanfattning : Obesity is a major health problem because of its dramatic increase in prevalence and its association with type 2 diabetes, coronary heart diseases, hypertension and stroke. It is well known that signals generated in response to feeding behavior are integrated in the brain. LÄS MER

5. 24. Endogenous and exogenous glucocorticoid effects in a model of allergic airway inflammation

   Författare :Susanna Kumlien Georén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Airway; allergy; asthma; eosinophil; glucocorticoids; hypothalamus-pituitary-adrenal HPA axis; inflammation; nerve growth factor NGF ; neuroimmunology; psychoneuroimmunology; restraint; stress;

   Sammanfattning : Allergic asthma and rhinitis are inflammatory diseases of the airways. Allergic asthma is characterized by eosinophilic inflammation, reversible bronchoconstriction and airway hyperresponsiveness, whereas patients with rhinitis suffer from nasal inflammation, leading to rhinorrhea and nasal congestion. LÄS MER

7. 25. Brain control of energy balance : localization and regulation of proteins involved in the central control of food intake and body weight

   Författare :Maria Collin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AGRP; arcuate nucleus; brainstem; CART; GABA; Glutamate; GPCR; habenular complex; immunohistochemistry; in situ hybridization; hypothalamus; leptin; leptin receptor; LHA; MCH; NPY; Ob-Rb; POMC; serotonin; STAT3; transporter; ventromedial hypothalamic nucleus; VGLUT1-3.;

   Sammanfattning : Obesity has become a worldwide threat to human well-being and is now so common that it is beginning to replace undernutrition and infectious disease as the most significant contributor to ill health. Obesity increases the risk for aquiring serious diseases such as diabetes type 2, hypertension, coronary heart disease and certain forms of cancer. LÄS MER