Sökning: "IL-6Rα"

Hittade 3 avhandlingar innehållade ordet IL-6Rα.

1. 1. IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice

   Författare :Fredrik Anesten; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6Rα; GLP-1; obesity; hypothalamus; brainstem; tanycytes; immunohistochemistry;

   Sammanfattning : It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ICV- injections, but not peripheral injections of IL-6, increases energy expenditure and decreases body fat in rodents. LÄS MER

3. 2. Body fat regulating neuropeptides: relation to interleukines and gut microbiota

   Författare :Erik Schéle; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6 receptor a; obesity; hypothalamus; brainstem; immunohistochemistry;

   Sammanfattning : Previous studies have shown that mice lacking interleukin-6 (IL-6), an important cytokine in the immune system, develop obesity, and that central, but not peripheral, administration of IL-6 induces energy expenditure. These findings suggest that IL-6 suppresses fat mass through the central nervous system. LÄS MER

4. 3. Inflammatory Signaling Across the Blood-Brain Barrier and the Generation of Fever

   Författare :Anna Eskilsson; David Engblom; Annika Thorsell; Göran Engberg; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Fever is a cardinal sign of inflammation and is evolutionary conserved. Fever is known to be beneficial during acute inflammation, but over time and if very high it can be detrimental. LÄS MER