Sökning: "hypothalamic obesity"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden hypothalamic obesity.

  1. 1. Genes implicated in the development of obesity and obesity-related disease

    Författare :Kajsa Lindell; Göteborgs universitet; []
    Nyckelord :obesity; adipose tissue; hypothalamus; leptin; leptin receptor; 5 untranslated region; hypertension; angiotensinogen; DNA microarray;

    Sammanfattning : Obesity is a major health problem because of its dramatic increase in prevalence and the association of obesity with type 2 diabetes, coronary heart disease, hypertension and stroke. Although mutations in certain genes have been shown to cause obesity, the molecular mechanisms underlying obesity and obesity-related disease are still largely unknown. LÄS MER

  3. 2. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease

    Författare :Rana Soylu Kucharz; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s Disease; Huntingtin; Hypothalamus; Metabolism; Obesity; orexin; PVN; BAT; TH; neuroendocrinology;

    Sammanfattning : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. LÄS MER

  4. 3. Cytokines in Metabolic Functions

    Författare :Anna Benrick; Göteborgs universitet; []
    Nyckelord :IL-1; IL-6; LIF; obesity; fat mass; energy expenditure; hypothalamus; gp130 SNP; myocardial infarction;

    Sammanfattning : During infections, circulating cytokines are largely produced by immune cells. In healthy obese individuals, large parts of these circulating cytokines are produced in adipose tissue, for instance by macrophages that have accumulated there. LÄS MER

  5. 4. From Food Preference to Craving : Behavioural Traits and Molecular Mechanisms

    Författare :Johan Alsiö; Helgi B Schiöth; Jonas Lindblom; Anna M Kindlundh-Högberg; Suzanne Dickson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; Reward; Food preferences; Dietary fats; Dietary carbohydrates; Anxiety; Dopamine; Craving; Operant self-administration; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Sammanfattning : Preference for palatable and energy-dense foods may be a risk factor for body weight gain and has both genetic and environmental components. Once obesity develops in an individual, weight loss is difficult to achieve. LÄS MER

  7. 5. Body fat regulating neuropeptides: relation to interleukines and gut microbiota

    Författare :Erik Schéle; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6 receptor a; obesity; hypothalamus; brainstem; immunohistochemistry;

    Sammanfattning : Previous studies have shown that mice lacking interleukin-6 (IL-6), an important cytokine in the immune system, develop obesity, and that central, but not peripheral, administration of IL-6 induces energy expenditure. These findings suggest that IL-6 suppresses fat mass through the central nervous system. LÄS MER