Sökning: "cocaine- and amphetamine-regulated transcript"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden cocaine- and amphetamine-regulated transcript.

1. 1. The role of cocaine- and amphetamine-regulated transcript in endocrine cells

   Författare :Liliya Shcherbina; Neuroendokrin cellbiologi; []
   Nyckelord :Type 2 Diabetes; T2D; cocaine and amphetamine-regulated transcript; CART; beta-cell; K-cell; L-cell; insulin; GIP; GLP-1; incretin hormones;

   Sammanfattning : Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. LÄS MER

3. 2. The role of CART in islet function

   Författare :Mia Abels; Neuroendokrin cellbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

   Sammanfattning : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. LÄS MER

4. 3. Central and Peripheral Neuroendocrine Factors in Cancer-Associated Anorexia and Cachexia

   Författare :Jonathan R Burgos; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer anorexia-cachexia syndrome; inflammation; TSH receptor; cocaine- and amphetamine-regulated transcript; nesfatin-1; CRH; hypothalamus; brainstem; MCG101;

   Sammanfattning : Cancer anorexia-cachexia syndrome (CACS) develops in response to tumor-host biochemical interactions. A loss of appetite (anorexia) and increased metabolism results in a progressive wasting of adipose and skeletal muscle tissues (cachexia). LÄS MER

5. 4. New actors in adipocyte function -Focusing on PDEs, CART and superantigen

   Författare :Elin Banke; Signaltransduktionsforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Obesity is increasing rapidly in all parts of the world and is now considered to be a global epidemic. Obesity is a major risk factor for several health issues such as type 2 diabetes (T2D) and cardiovascular disease. LÄS MER

7. 5. A MATTER OF NUTRIENT EXCESS AND SHEAR STRESS

   Författare :Ramasri Sathanoori; Kardiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. LÄS MER