Sökning: "hyperfiltration"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet hyperfiltration.

1. 6. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress

   Författare :Patrik Persson; Fredrik Palm; Peter Hansell; Bengt Rippe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; diabetic nephropathy; glomerular filtration rate; renal blood flow; insulin; renal hemodynamics; micropuncture; oxygen; NADPH-oxidase; apocynin; streptozotocin; l-arginine; CGS21680; rats; mice; Physiology; Fysiologi; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. LÄS MER

3. 7. Diabetes-induced Alterations in Renal Microcirculation and Metabolism

   Författare :Fredrik Palm; Per Liss; Peter Hansell; Per-Ola Carlsson; Gerald DiBona; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; diabetes mellitus; kidney; nephropathy; oxygen tension; haemodynamic; nitric oxide; oxygen consumption; radical oxygen species; polyol pathway; Fysiologi; Physiology; Fysiologi;

   Sammanfattning : Diabetes-induced renal complications, i.e. diabetes nephropathy, are a major cause of morbidity and mortality. The exact mechanism mediating the negative influence of hyperglycaemia on renal function is unclear, although several hypotheses have been postulated. LÄS MER

4. 8. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

   Författare :Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. LÄS MER

5. 9. Pathomechanism of diabetic nephropathy

   Författare :Anna Körner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :diabetic nephropathy; hyperflltration; Na ; K - ATPase; Dahl rats; salt sensitive hypertension; glomerulosclerosis; polyol pathway activation; oxidative stress;

   Sammanfattning : Diabetic nephropathy is today the most common cause of end stage renal failure. The risk for developing overt diabetic nephropathy is considerably reduced by antihypertensive treatment, and adequate control of blood glucose. However, there is a need for additional and even more efficient tools to prevent this complication of diabetes. LÄS MER

7. 10. PLASMA PROTEINS IN NORMAL AND PREECLAMPTIC PREGNANCY

   Författare :Karl Kristensen; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gynaecology; andrology; reproduction; sexuality; Obstetrik; Obstetrics; pregnancy; renal function; serum amyloid A protein; Clinical chemistry; Klinisk kemi; preeclampsia; beta-2 microglobulin; C-reactive protein; cystatin C; inflammation; placenta; beta trace protein; gynekologi; andrologi; reproduktion; sexualitet;

   Sammanfattning : The aim of the research presented in this thesis was to provide extended background knowledge concerning several biochemical markers, used for the medical evaluation of pregnant women with suspected or confirmed preeclampsia, in order to improve the reliability of monitoring. Plasma levels of beta-2 microglobulin, cystatin C and beta trace protein are known to reflect renal filtration in non-pregnant settings, and the plasma proteins, C-reactive protein and serum amyloid A protein, are known to be sensitive markers of inflammation. LÄS MER