Sökning: "Coenzyme Q10"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Coenzyme Q10.

  1. 1. Influence of Oxidative Stress on Muscle and Bone

    Författare :Bengt Östman; Karl Michaëlsson; Lars Nordsletten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone mineral density; coenzyme Q10; exercise; ischaemia; isprostanes; muscle; oxidative stress; oxygen radicals; reperfusion; tocopherol; Orthopaedics; Ortopedi; ortopedi; Orthopaedics;

    Sammanfattning : Reactive oxygen species (ROS) induce oxidative stress and although are primarily recognized for playing a deleterious biological role, they can be beneficial to cell systems. ROS are extremely short-lived and normally tightly regulated by antioxidant defence systems. LÄS MER

  3. 2. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

    Författare :Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. LÄS MER

  4. 3. Post-polio syndrome : physiotherapeutic analysis and interventions

    Författare :Katarina Skough; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Post-polio syndrome;

    Sammanfattning : This thesis presents four studies focusing on outcomes of gait performance using gait analysis and/or the Six-minute-walk test (6MWT), in patients with post-polio syndrome (PPS). Further, resistance training in combination with Coenzyme Q10 (Q10) and intravenous immunoglobulin treatment (IvIg) in PPS patients was evaluated. LÄS MER

  5. 4. Reconstitution of Membrane-Bound Enzymes for Neutron Scattering Studies: A Case Study of Human Dihydroorotate Dehydrogenase

    Författare :Manuel Orozco; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; dihydroorotate dehydrogenase; pyrimidine metabolism; neutron scattering; ubiquinone; QCM-D;

    Sammanfattning : Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. LÄS MER

  7. 5. Translational studies on mitochondrial function and hypoxia in complications of diabetes mellitus

    Författare :Cheng Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DMassociated morbidity and mortality is mediated by diabetic complications. Hypoxia and oxidative stress have emerged as key players in the pathogenesis of various macro- and microvascular complications of DM. LÄS MER