Sökning: "folate metabolism"
Visar resultat 1 - 5 av 23 avhandlingar innehållade orden folate metabolism.
1. Examining the role of metabolism in Myc-driven tumorigenesis
Sammanfattning : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis. MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. LÄS MER
2. Folate, Hormones and Infertility : Different factors affecting IVF pregnancy outcome
Sammanfattning : Various hormones have been studied as regards prediction of pregnancy outcome after infertility treatment, but no ideal candidate has been found. Folate and genetic variations in folate metabolism have also been associated with infertility, but it remains unclear how these factors affect IVF pregnancy outcome. LÄS MER
3. Biomarkers of one-carbon metabolism in colorectal cancer risk
Sammanfattning : One-carbon metabolism, a network of enzymatic reactions involving the transfer of methyl groups, depends on B-vitamins as cofactors, folate as a methyl group carrier, and amino acids, betaine, and choline as methyl group donors. One-carbon metabolism influences many processes in cancer initiation and development such as DNA synthesis, genome stability, and histone and epigenetic methylation. LÄS MER
4. Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status
Sammanfattning : Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer risk at high fiber intake. LÄS MER
5. Vascular mechanisms in dementia with special reference to folate and fibrinolysis
Sammanfattning : The aim of this thesis was to study the biomarker homocysteine and other novel potential vascular risk factors for dementia. In an out-patient based study of a cohort of 926 consecutive subjects referred to our Memory Unit during 1996―2000, serum-folate was lower and total plasma homocysteine (tHcy) and serum methyl malonate were higher in subjects being prescribed with B12. LÄS MER