Sökning: "Pim-3 Kinase"

Hittade 2 avhandlingar innehållade orden Pim-3 Kinase.

1. 1. Examining the role of metabolism in Myc-driven tumorigenesis

   Författare :Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

   Sammanfattning : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. LÄS MER

3. 2. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

   Författare :Linus Plym Forshell; Jonas Nilsson; Lars-Gunnar Larsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Myc; Decitabine; Pim kinase; RCAS-tva; Neurobiology; Neurobiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. LÄS MER