Sökning: "ciprofloxacin"

Visar resultat 6 - 10 av 64 avhandlingar innehållade ordet ciprofloxacin.

1. 6. Biased Evolution : Causes and Consequences

   Författare :Gerrit Brandis; Diarmaid Hughes; Erik Böttger; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Codon usage bias; Post-transcriptional regulation; Recombination; Inversion; EF-Tu; Frameshift suppression; Antibiotic resistance; Rifampicin; Ciprofloxacin; Compensatory evolution; Drug efflux; RNA polymerase; DNA gyrase; Mikrobiologi; Microbiology;

   Sammanfattning : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. LÄS MER

3. 7. Host-parasite interaction in men with febrile urinary tract infection

   Författare :Peter Ulleryd; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urinary tract infection; fever; male; Escherichia coli; serotype; virulence; PSA; prostate; prostatitis; TRUS; urography; cystoscopy; treatment; ciprofloxacin;

   Sammanfattning : In a retrospective study, Escherichia coli isolates from 88 men with symptomatic urinary tract infection (UTI) were analysed. A wide array of O:K:H serotypes commonly associated with acute pyelonephritis in women were identified. LÄS MER

4. 8. Host-Pathogen Interactions in Pseudomonas aeruginosa Invasive and Respiratory Tract Infection

   Författare :Magnus Paulsson; Malmö Klinisk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseudomonas aeruginosa; vitronectin; Respiratory tract infections; Innate Immunity; outer membrane vesicles; outer membrane proteins; beta-lactamase; ciprofloxacin; combination treatment; bacteraemia; Complement escape;

   Sammanfattning : Pseudomonas aeruginosa is an opportunistic bacterium that causes debilitating infections when the immune defence is compromised. It possesses an arsenal of virulence traits to colonize most compartments of the body and is often highly resistant against commonly used antimicrobial drugs. LÄS MER

5. 9. Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects

   Författare :David D. Khan; Lena Friberg; Hartmut Derendorf; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Pharmacokinetics; Pharmacodynamics; PKPD modeling; ciprofloxacin; colistin; E. coli; antibiotics; time-kill experiments; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. LÄS MER

7. 10. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

   Författare :Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
   Nyckelord :pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. LÄS MER