Sökning: "EF-Tu"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet EF-Tu.

  1. 1. EF-Tu and RNase E : Essential and Functionally Connected Proteins

    Författare :Disa L. Hammarlöf; Diarmaid Hughes; Måns Ehrenberg; Gerhart Wagner; Richard H Buckingham; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacterial growth; translation; EF-Tu; RNase E; mRNA; RNA degradation; Molekylär cellbiologi; Molecular Cellbiology; Mikrobiologi; Microbiology;

    Sammanfattning : The rate and accuracy of protein production is the main determinant of bacterial growth. Elongation Factor Tu (EF-Tu) provides the ribosome with aminoacylated tRNAs, and is central for its activity. In Salmonella enterica serovar Typhimurium, EF-Tu is encoded by the genes tufA and tufB. LÄS MER

  3. 2. Genetics and Growth Regulation in Salmonella enterica

    Författare :Jessica M. Bergman; Diarmaid Hughes; Dan I. Andersson; Måns Ehrenberg; Stanley Maloy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tufA; tufB; EF-Tu; ppGpp; Stringent response; RNase E; RNA turnover; Post-transcriptional regulation; rpoB; rpoS; Growth in stationary phase; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Mikrobiologi; Microbiology; Molekylär genetik; Molecular Genetics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

    Sammanfattning : Most free-living bacteria will encounter different environments and it is therefore critical to be able to rapidly adjust to new growth conditions in order to be competitively successful. Responding to changes requires efficient gene regulation in terms of transcription, RNA stability, translation and post-translational modifications. LÄS MER

  4. 3. Biased Evolution : Causes and Consequences

    Författare :Gerrit Brandis; Diarmaid Hughes; Erik Böttger; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Codon usage bias; Post-transcriptional regulation; Recombination; Inversion; EF-Tu; Frameshift suppression; Antibiotic resistance; Rifampicin; Ciprofloxacin; Compensatory evolution; Drug efflux; RNA polymerase; DNA gyrase; Mikrobiologi; Microbiology;

    Sammanfattning : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. LÄS MER

  5. 4. A Unified Multitude : Experimental Studies of Bacterial Chromosome Organization

    Författare :Eva Garmendia; Diarmaid Hughes; Linus Sandegren; John R. Roth; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bacterial evolution; chromosome organization and structure; chromosomal inversions; EF-Tu; horizontal gene transfer; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Bacteria are many, old and varied; different bacterial species have been evolving for millions of years and show many disparate life-styles and types of metabolism. Nevertheless, some of the characteristics regarding how bacteria organize their chromosomes are relatively conserved, suggesting that they might be both ancient and important, and that selective pressures inhibit their modification. LÄS MER

  7. 5. Exotic Ribosomal Enzymology

    Författare :Josefine Liljeruhm; Anthony C. Forster; Christophe Danelon; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; rRNA modification; Methyltransferase; RlmM; RlmJ; D-amino acid; Unnatural amino acid; Chromoprotein; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : This thesis clarifies intriguing enzymology of the ribosome, the multiRNA/multiprotein complex that catalyzes protein synthesis (translation). The large ribosomal RNAs (23S and 16S rRNAs in E. coli) are post-transcriptionally modified by many specific modification enzymes, yet the functions of the modifications remain enigmatic. LÄS MER