Sökning: "Diarmaid Hughes"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Diarmaid Hughes.

1. 1. Studies on the functional interaction of translation initiation factor IF1 with ribosomal RNA

   Författare :Jaroslav Belotserkovsky; Leif Isaksson; Diarmaid Hughes; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome; rRNA mutation; molekylärgenetik; Molecular Genetics;

   Sammanfattning : Translation initiation factor IF1 is a small, essential and ubiquitous protein factor encoded by a single infA gene in bacteria. Although several important functions have been attributed to IF1, the precise reason for its indispensability is yet to be defined. LÄS MER

3. 2. Genetics and Growth Regulation in Salmonella enterica

   Författare :Jessica M. Bergman; Diarmaid Hughes; Dan I. Andersson; Måns Ehrenberg; Stanley Maloy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tufA; tufB; EF-Tu; ppGpp; Stringent response; RNase E; RNA turnover; Post-transcriptional regulation; rpoB; rpoS; Growth in stationary phase; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Mikrobiologi; Microbiology; Molekylär genetik; Molecular Genetics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Sammanfattning : Most free-living bacteria will encounter different environments and it is therefore critical to be able to rapidly adjust to new growth conditions in order to be competitively successful. Responding to changes requires efficient gene regulation in terms of transcription, RNA stability, translation and post-translational modifications. LÄS MER

4. 3. Biased Evolution : Causes and Consequences

   Författare :Gerrit Brandis; Diarmaid Hughes; Erik Böttger; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Codon usage bias; Post-transcriptional regulation; Recombination; Inversion; EF-Tu; Frameshift suppression; Antibiotic resistance; Rifampicin; Ciprofloxacin; Compensatory evolution; Drug efflux; RNA polymerase; DNA gyrase; Mikrobiologi; Microbiology;

   Sammanfattning : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. LÄS MER

5. 4. A Unified Multitude : Experimental Studies of Bacterial Chromosome Organization

   Författare :Eva Garmendia; Diarmaid Hughes; Linus Sandegren; John R. Roth; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bacterial evolution; chromosome organization and structure; chromosomal inversions; EF-Tu; horizontal gene transfer; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Bacteria are many, old and varied; different bacterial species have been evolving for millions of years and show many disparate life-styles and types of metabolism. Nevertheless, some of the characteristics regarding how bacteria organize their chromosomes are relatively conserved, suggesting that they might be both ancient and important, and that selective pressures inhibit their modification. LÄS MER

7. 5. Exploring the Ciprofloxacin Resistome

   Författare :Linnéa Garoff; Diarmaid Hughes; Jesús Blázquez; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Experimental evolution; Ciprofloxacin; Escherichia coli; Mikrobiologi; Microbiology;

   Sammanfattning : This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug target binding, increasing drug efflux, and modifying the drug. LÄS MER