Sökning: "Complement escape"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Complement escape.

  1. 1. Complement evasion strategies of human pathogens - the evolutionary arms race

    Författare :Monika Jusko; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complement system; pathogen; periodontitis; proteases; immune escape;

    Sammanfattning : Although the complement system, a pivotal component of innate immunty, is centrally involved in host defense against pathogens, its overactivation or deregulation may excessively amplify inflammation and contribute to immunopathology. Periodontitis, an oral infection-driven chronic inflammatory disease, has been linked with complement disruption by periodontal bacteria, resulting in inflammation and pathogenesis. LÄS MER

  3. 2. Host-Pathogen Interactions in Pseudomonas aeruginosa Invasive and Respiratory Tract Infection

    Författare :Magnus Paulsson; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseudomonas aeruginosa; vitronectin; Respiratory tract infections; Innate Immunity; outer membrane vesicles; outer membrane proteins; beta-lactamase; ciprofloxacin; combination treatment; bacteraemia; Complement escape;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic bacterium that causes debilitating infections when the immune defence is compromised. It possesses an arsenal of virulence traits to colonize most compartments of the body and is often highly resistant against commonly used antimicrobial drugs. LÄS MER

  4. 3. Immune cell infiltration and prognosis in colorectal cancer

    Författare :Agnes Ling; Richard Palmqvist; Sofia Edin; Xingru Li; Ola Winqvist; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Colorectal cancer; molecular subgroups; immune cell infiltration; immune escape; prognosis;

    Sammanfattning : Background: Colorectal cancer (CRC) is globally the second most common form of cancer among women, and third in men. It is also one of the most common causes of cancer-related death in high-income countries. Surgical resection is the basis for curative therapy but still almost half of the patients die from metastatic disease. LÄS MER

  5. 4. Interactions between Streptococcus pyogenes and the human immune defence

    Författare :Maria E Nilsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M protein; Streptococcus pyogenes; Streptolysin O; The complement system; Neutrophils; Biomedical sciences; Biomedicinska vetenskaper; General biomedical sciences; Biomedicinska vetenskaper allmänt ; Microbiology; transplantation; Immunology; serology; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; Immunologi; serologi; Infections; Infektioner; Clinical biology; Klinisk biologi; bacteriology;

    Sammanfattning : Streptococcus pyogenes is an important human pathogen frequently colonizing the throat and skin of humans. To facilitate colonization and spread and to avoid the host immune defence, streptococci are endowed with a variety of virulence factors, two of which are investigated in this thesis namely streptolysin O (SLO) and M protein. LÄS MER

  7. 5. Molecular studies of Neisseria : host cell interactions

    Författare :Anne Rytkönen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Neisseria family includes many non-pathogenic species but also two strict human pathogens; Neisseria gonorrhoeae and Neisseria meningitidis. Both organisms colonise mucosal surfaces and may cause disseminated infections upon passage of the epithelial barrier. LÄS MER