Sökning: "Frameshift suppression"

Hittade 5 avhandlingar innehållade orden Frameshift suppression.

  1. 1. Frameshifting as a tool in analysis of transfer RNA modification and translation

    Författare :Ramune Leipuviene; Glenn Björk; Diana Downs; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; minor tRNA; frameshifting; suppression; L9; hopping; tRNA thiolation; [Fe-S] cluster; [Fe-S] protein; TtcA; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. LÄS MER

  3. 2. Biased Evolution : Causes and Consequences

    Författare :Gerrit Brandis; Diarmaid Hughes; Erik Böttger; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Codon usage bias; Post-transcriptional regulation; Recombination; Inversion; EF-Tu; Frameshift suppression; Antibiotic resistance; Rifampicin; Ciprofloxacin; Compensatory evolution; Drug efflux; RNA polymerase; DNA gyrase; Mikrobiologi; Microbiology;

    Sammanfattning : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. LÄS MER

  4. 3. Translational termination, frameshift and ribosome assembly

    Författare :Monica Rydén Aulin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The aim of this thesis was to study components involved in translational termination. Most of the work is centered around this, but the outcome of some of the experiments, led me onto other paths too.Firstly, isolation of a mutant which was shown to be in release factor one, was mapped to min 26,5 on the Escherichia coli chromosome. LÄS MER

  5. 4. Lineage stability and effector function of CD4+FOXP3+ regulatory T cells

    Författare :Christina Seitz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Treg cells are crucial in maintaining immunological tolerance and they in part act by suppressing dendritic cells (DCs). LÄS MER

  7. 5. Evolutionary consequences of dominance at the Brassicaceae self-incompatibility locus

    Författare :Jörg Alexander Bachmann; Tanja Slotte; Vincent Castric; Ove Eriksson; Pär Ingvarsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Capsella; mating system shift; self-fertilization; self-incompatibility; small RNA; dominance; Arabidopsis; population genetics; genomics; gene expression; ekologi och evolution; Ecology and Evolution;

    Sammanfattning : Self-incompatibility (SI) is a genetic mechanism that allows plants to enforce outcrossing by rejecting self-pollen and pollen from close relatives. In the Brassicaceae, SI is sporophytic and controlled by the self-incompatibility locus (S-locus). LÄS MER