Sökning: "carboxypeptidase E"

Hittade 5 avhandlingar innehållade orden carboxypeptidase E.

  1. 1. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo

    Författare :Quan Wen; Anders Forslund; Hannes Manell; Hjalti Kristinsson; Lisa Juntti-Berggren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha cell; carboxypeptidase E; childhood obesity; DRP-1; free fatty acids; glucagon secretion; glucose metabolism; glucose stimulated insulin secretion; human islets; hyperinsulinemia; metformin; mitochondrial fission; oral glucose tolerance test OGTT ; prohormone convertase; proinsulin; proinsulin to insulin ratio PI:I ;

    Sammanfattning : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. LÄS MER

  3. 2. Lung Microenvironments Influence on Mast Cell Plasticity and Spatial Distribution of Immune cells

    Författare :Premkumar Siddhuraj; Luftvägsinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; medicine; lung diseases;

    Sammanfattning : Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. LÄS MER

  4. 3. Mast Cells as Sentinels : Role of serglycin and mast cell proteases in infection and inflammation

    Författare :Ananya Roy; Magnus Åbrink; Olaf Utermöhlen; Uppsala universitet; []
    Nyckelord :mast cells; serglycin; chymase; infection; parasite; Immunologi; Immunology;

    Sammanfattning : Mast cells (MCs), normally classified into connective tissue MCs and mucosal MCs, are highly granulated cells found in the interface between the interior and the exterior environment of our body, e.g. skin, airways and gastro-intestinal tract. LÄS MER

  5. 4. Pharmacological interactions between angiotensin-converting enzyme (ACE) inhibitors, bradykinin and nitric oxide

    Författare :Karin Persson; Karl-Erik Andersson; Linköpings universitet; []
    Nyckelord :angiotensin-converting enzyme; angiotensin-converting enzyme inhibitors; atherosclerosis; bradykinin; endothelium; in vitro; nitric oxide; MEDICINE; MEDICIN;

    Sammanfattning : Cardiovascular diseases are a major cause of death in Western countries. Angiotensin-converting enzyme (ACE) is as a key enzyme in the renin-angiotensin system involved in the regulation of blood pressure, and water and electrolyte balance in the body. LÄS MER

  7. 5. Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions

    Författare :Jovan P Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thrombin activatable fibrinolysis inhibitor TAFI ; coagulation; fibrinolysis; thrombin; plasmin; factor V Leiden; hemophilia; von Willebrand disease; diabetes mellitus; preeclampsia;

    Sammanfattning : Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept by giving thrombin, the pivotal enzyme in hemostasis, another important role in the down-regulation of fibrinolysis. LÄS MER