Sökning: "human islets"

Visar resultat 1 - 5 av 161 avhandlingar innehållade orden human islets.

1. 1. Free fatty acids and insulin hypersecretion studied in human islets

   Författare :Jing Cen; Peter Bergsten; Miriam Cnop; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; free fatty acids; palmitate; human islets; EndoC-βH1 cells; metformin; sorcin; insulin secretion; mitochondrial respiration; ER stress; human transcriptome array; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Free fatty acid (FFA) levels are increased in many obese subjects. High FFA levels stimulate the pancreatic beta-cells but have negative long-term effects. In obese children with high FFA levels circulating insulin concentration is high early in life but decline with age precipitating the development of type 2 diabetes mellitus (T2DM). LÄS MER

3. 2. Characterization of the Pancreas in Type 1 and Type 2 Diabetes

   Författare :Marcus Lundberg; Oskar Skog; Olle Korsgren; Martha Campbell-Thompson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; HbA1c; interferon-stimulated genes; parasympathetic; axon; cellular stress; islets; exocrine; immunology; leucocytes; inflammation; human; pancreas; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology; Patologi; Pathology;

   Sammanfattning : Diabetes is recognized by hyperglycaemia and polyuria. Complications, reduced quality of life and staggering health-care costs are all derived from the disease. Two subclasses of diabetes are Type 1 diabetes (T1D) and Type 2 diabetes (T2D). LÄS MER

4. 3. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

   Författare :Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
   Nyckelord :Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

   Sammanfattning : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. LÄS MER

5. 4. Study of DNA methylation in human pancreatic islets

   Författare :Elin Hall; Diabetes - epigenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; epigenetics; DNA mehtylation; human pancreatic islets; insulin secretion;

   Sammanfattning : Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. LÄS MER

7. 5. Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans

   Författare :Annika Moëll; Gun Frisk; Olle Korsgren; Bo Nilsson; Outi Vaarala; Uppsala universitet; []
   Nyckelord :Immunology; diabetes; islets of Langerhans; enterovirus; inflammatory mediators; cytokines; nicotinamide; Immunologi;

   Sammanfattning : Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. LÄS MER