Sökning: "serglycin"

Hittade 5 avhandlingar innehållade ordet serglycin.

  1. 1. Mast Cells as Sentinels : Role of serglycin and mast cell proteases in infection and inflammation

    Författare :Ananya Roy; Magnus Åbrink; Olaf Utermöhlen; Uppsala universitet; []
    Nyckelord :mast cells; serglycin; chymase; infection; parasite; Immunologi; Immunology;

    Sammanfattning : Mast cells (MCs), normally classified into connective tissue MCs and mucosal MCs, are highly granulated cells found in the interface between the interior and the exterior environment of our body, e.g. skin, airways and gastro-intestinal tract. LÄS MER

  3. 2. Serglycin-dependent mast cell-specific proteases and their potential interactions with Giardia intestinalis

    Författare :Zhiqiang Li; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mast cells are located in mucosal and connective tissues throughout the body where they play important roles in immune reactions towards infections. Mast cell deficiency results in failure of clearance of the non-invasive intestinal protozoan parasite Giardia intestinalis in mice, but the mast cell-driven mechanisms remain poorly understood. LÄS MER

  4. 3. The response of mast cells and serglycin-dependent proteases to parasitic infection : studies on mast cells during Toxoplasma gondii (murine) and Dictyocaulus vivparus (bovine) infection

    Författare :Osama Sawesi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The proteoglycan (PG), serglycin (SG), is expressed in several hematopoietic cells and studies of the SG knockout mice (SG-/-) revealed prominent effects on the storage of certain mouse mast cell proteases (mMCPs) such as mMCP-4, -5 and -6.In this thesis, the role of SGPG during parasitic infection was addressed. LÄS MER

  5. 4. The role of mast cell proteases in allergic disease and apoptosis

    Författare :Ida Waern; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Mast cells (MCs) are key effector cells in allergic reactions, through the release of a wide variety of granule-stored and de novo synthesized inflammatory mediators. The MC secretory granules contain exceedingly high levels of serglycin proteoglycan and the heparin-binding proteases chymase, tryptase and carboxypeptidase A. LÄS MER

  7. 5. Complement in Disease - Extracellular Proteins as Complement Regulators

    Författare :Kaisa Happonen; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Sammanfattning : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. LÄS MER