Sökning: "axonal tracing"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden axonal tracing.

  1. 1. In vivo properties of neural stem cells after transplantation into the rat brain-Studies of phenotypic differentiation and functional integration using cell-specific labelling and electrophysiological techniques

    Författare :Ulrica Englund Johansson; Peter Eriksson; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell line; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; functional integration; electrophysiology; retrograde tracing; immortalized; GFP; migration; axonal projections; glia; neuron; transplantation; stem cell. progenitor cell; CNS; Biomedical Sciences;

    Sammanfattning : In the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). LÄS MER

  3. 2. Zinc-enriched neurons in the spinal cord, cerebellum and peripheral sympathetic system

    Författare :Zhan-You Wang; Göteborgs universitet; []
    Nyckelord :autometallography; axonal transport; confocal laser scanning microscopy; immuno-electron microscopy; immunofluorescence; inhibitory neurons; sympathetic neurons; synaptic vesicles; zinc ions; zinc transporter;

    Sammanfattning : Zinc ions are abundant in the nervous system and are involved in many biological functions. Most zinc is tightly bound to macromolecules, whereas a small fraction of zinc exists in synaptic vesicles of the zinc-enriched (ZEN) neurons, and can be visualized using various histochemical techniques, including autometallography (AMG). LÄS MER

  4. 3. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair

    Författare :Tiago Cardoso; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rabies-based tracing; Parkinson s disease cell therapy; Cell Replacement Therapy; Human embryonic stem cells; Dopamine neuron; Synaptic integration; circuitry repair;

    Sammanfattning : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. LÄS MER

  5. 4. Spinal cord repair strategies

    Författare :Henrich Cheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; injury; paraplegia; repair; regeneration; nerve graft; fibrin glue; aFGF; GDNF; gait; axonal tracing Henrich Cheng; 1996;

    Sammanfattning : Regeneration of long fiber tracts does not occur spontaneously in the adult mammalian brain or spinal cord. The present work is an attempt to develop a repair strategy that may overcome this lack of recovery and apply it to spinal cord injury. LÄS MER

  7. 5. Cell therapy for spinal cord injury, studies of motor and sensory systems

    Författare :Christoph Hofstetter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nervous system; spinal cord injury; pseudorabies virus; axonal tracing; functional MRI; stereology; Rho-kinases; transplantation; stem cells; neurogenin2; allodynia;

    Sammanfattning : Spinal cord injury represents a significant medical concern, affecting thousands of individuals each year. The majority of victims are young males harmed by traffic accidents, violence, and falls. Severe spinal cord injury interupts nerve fiber pathways connecting the brain and the rest of the body. LÄS MER