Sökning: "Rabies-based tracing"

Hittade 1 avhandling innehållade orden Rabies-based tracing.

1. 1. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair

   Författare :Tiago Cardoso; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rabies-based tracing; Parkinson s disease cell therapy; Cell Replacement Therapy; Human embryonic stem cells; Dopamine neuron; Synaptic integration; circuitry repair;

   Sammanfattning : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. LÄS MER