Sökning: "allodynia"

Visar resultat 1 - 5 av 34 avhandlingar innehållade ordet allodynia.

  1. 1. A clinical image of migraine. On prevalence, impact of disease, natural course of attacks and influence of 5-HT1B/1D-agonists

    Författare :Mattias Linde; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :migraine; epidemiology; Sweden; burden; quality of life; natural course; triptans; sensitization; allodynia; hyperalgesia;

    Sammanfattning : The first, large nationwide survey of the epidemiology of migraine in Sweden was performed. The one-year prevalence is 13.2 b1.9% (16. LÄS MER

  2. 2. A tailored biocompatible neural interface for long term monitoring in neural networks

    Författare :Per Köhler; Neuronano Research Center (NRC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Brain-machine interfaces; neuroinflammation; somatosensory cortex; hyperalgesia; allodynia;

    Sammanfattning : Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain parenchyma. LÄS MER

  3. 3. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

    Författare :Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. LÄS MER

  4. 4. Dynamic mechanical allodynia in peripheral neuropathic pain : Psychological observations

    Författare :Monika Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Dynamic mechanical allodynia; Brush-evoked allodynia; Brush-evoked pain; Neuropathic pain; Pain descriptors; Repeatability; Human pain model; Capsaicin; Psychophysical observations;

    Sammanfattning : Introduction and aim: Pain due to a light moving mechanical stimulus, dynamic mechanical allodynia, is a protruding symptom/sign in subgroups of patients with peripheral neuropathic pain and frequently as troublesome as spontaneous ongoing pain. The objective of this thesis was to survey psychophysical details of dynamic mechanical allodynia using a novel semi-quantitative method. LÄS MER

  5. 5. Experimental tooth clenching : a model for studying mechanisms of muscle pain

    Författare :Andreas Dawson; Malmö högskola; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tooth clenching; muscle pain; bruxism; Delphi technique; pain measurement; masticatory muscles; experimental pain; proprioceptive allodynia; temporomandibular disorders; serotonin; glutamate; masseter muscle; microdialysis;

    Sammanfattning : “I felt like I’d done three rounds with Mike Tyson…all becauseI was grinding my teeth in my sleep”, så beskrev en patient somintervjuades av Daily Mail i en artikel där det ökade problemet medöverbelastning i käkarna beskrevs, vilket kan leda till tandslitage,muskelsmärta, och frakturer på tandmaterial. Det personliga lidandet,och de ekonomiska kostnaderna för både individ och samhälle ärstort. LÄS MER